Adjustment of Treatment Regimen for a Child with Anti-Tuberculosis Drugs-Induced Liver Injury Based on Therapeutic Drug Monitoring

Lu Hong; Shi Qunzhi; Wu Ge; Liu Fangqun

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Adjustment of Treatment Regimen for a Child with Anti-Tuberculosis Drugs-Induced Liver Injury Based on Therapeutic Drug Monitoring

更新时间：2022-11-04

- Adjustment of Treatment Regimen for a Child with Anti-Tuberculosis Drugs-Induced Liver Injury Based on Therapeutic Drug Monitoring
- Vol. 28, Issue 8, Pages: 5-9(2022)
- 作者机构：
  
  南华大学附属长沙中心医院,长沙,410004
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2022，
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Lu Hong, Shi Qunzhi, Wu Ge, et al. Adjustment of Treatment Regimen for a Child with Anti-Tuberculosis Drugs-Induced Liver Injury Based on Therapeutic Drug Monitoring. [J]. 28(8):5-9(2022)
DOI：

Lu Hong, Shi Qunzhi, Wu Ge, et al. Adjustment of Treatment Regimen for a Child with Anti-Tuberculosis Drugs-Induced Liver Injury Based on Therapeutic Drug Monitoring. [J]. 28(8):5-9(2022) DOI：

摘要

目的：通过观察1例13岁儿童患者应用抗结核药物导致药物性肝损伤（DILI）的治疗过程，探讨临床药师在疾病预防和治疗中的作用。方法：临床药师参与1例儿童应用抗结核药物致DILI的治疗过程，根据抗结核药物治疗药物监测（TDM）结果提出用药建议，调整儿童抗结核药物的治疗方案。结果：临床医师部分采纳药师建议，调整用药方案，患儿病情和肝损伤明显改善。结论：TDM是临床药师参与药物治疗的有效技术手段，可保障疾病治疗过程中的用药安全有效。

Abstract

Objective: To probe into the role of clinical pharmacists in disease prevention and treatment through the treatment process of a 13-year-old child with drug-induced liver injury (DILI) induced by anti-tuberculous drugs. Methods: The clinical pharmacists participated into the treatment process of a child with DILI induced by anti-tuberculous drugs

put forward suggestions according to the results of therapeutic drug monitoring (TDM) on anti-tuberculous drugs

and adjusted the treatment regimen of anti-tuberculosis drugs in children. Results: The clinicians partly adopted the suggestions by clinical pharmacists and adjusted the medication regimen

the disease conditions and liver function of the children were significantly improved. Conclusion: TDM is an effective technical means for clinical pharmacists to participate into drug treatment

which can ensure the safety of drugs in disease treatment

关键词

药物性肝损伤抗结核药物治疗药物监测

Keywords

rug-induced liver injuryanti-tuberculosis drugstherapeutic drug monitoring

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