Relationship between irisin level in blood with obesity and type 2 diabetes mellitus

Zhang Shitian; Wang Yaru; Liu Ying; Wang Shuang; Li Xuan; Liu Rui; Zhang Yanan; Niu Wenyan

您当前的位置：

首页 >

文章列表页 >

Relationship between irisin level in blood with obesity and type 2 diabetes mellitus

更新时间：2022-06-28

- Relationship between irisin level in blood with obesity and type 2 diabetes mellitus
- Journal of Chongqing Medical University Vol. 47, Issue 4, Pages: 411-416(2022)
- 作者机构：
  
  天津医科大学朱宪彝纪念医院检验科、天津市内分泌研究所、国家卫健委激素与发育重点实验室、天津市代谢性疾病重点实验室,天津,300134
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2022，
扫描看全文
Zhang Shitian, Wang Yaru, Liu Ying, et al. Relationship between irisin level in blood with obesity and type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 47(4):411-416(2022)
DOI：

Zhang Shitian, Wang Yaru, Liu Ying, et al. Relationship between irisin level in blood with obesity and type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 47(4):411-416(2022) DOI：

摘要

目的：探讨血中鸢尾素水平与肥胖和2型糖尿病（type 2 diabetes mellitus，T2DM）相关指标的关系。方法：选取79例T2DM患者和非糖尿病对照80例，根据体质指数（body mass index，BMI）进一步分为正常组、肥胖组、T2DM组、T2DM肥胖组。应用全自动生化分析仪、全自动血糖检测仪、全自动糖化血红蛋白检测仪检测各组肥胖和T2DM相关指标，用酶联免疫吸附法检测血中鸢尾素、白细胞介素-1β（interleukin-1β，IL-1β）水平。采用方差分析和线性回归分析的方法分析数据。结果：T2DM肥胖组鸢尾素水平明显高于正常组，肥胖组和T2DM肥胖组鸢尾素水平明显高于T2DM组，糖尿病组IL-1β水平明显高于正常组，T2DM肥胖组IL-1β水平明显高于肥胖组。鸢尾素与体质量、BMI呈正相关。受试者工作特征（receiver operating character－istic，ROC）曲线结果显示鸢尾素在非糖尿病组、糖尿病组中的曲线下面积分别是0.653、0.854。结论：鸢尾素水平可能与肥胖存在一定的相关性，与T2DM不相关。鸢尾素在非糖尿病人群和糖尿病人群中对肥胖都有一定的辅助诊断价值。

Abstract

Objective：To discuss the relationship between irisin level in blood and obesity and type 2 diabetes mellitus（T2DM） related parameters. Methods：We recruited 79 T2DM patients and 80 non-diabetic controls. According to body mass index（BMI），these sub－jects were further divided into normal group，obese group，T2DM group，and T2DM obese group. Obesity and T2DM related parameters were measured by automated biochemical analyzer，automated glucose analyzer and automated glyco-hemoglobin analyzer，and the level of irisin and interleukin-1β（IL-1β） was tested by enzyme-linked immunosorbent assay（ELISA）. Analysis of variance（ANOVA） and linear regression analysis were used to analyze the data. Results：The irisin level in T2DM obese group was significantly higher than that in normal group. The irisin level in both obese and T2DM obese group was significantly higher than that in T2DM group. The IL-1β levels in diabetic groups were significantly higher than the level in normal group，and the level of IL-1β in T2DM obese group was significantly higher than that in obese group. Irisin was positively correlated to weight and BMI. The receiver operating character－istic（ROC） curve analysis showed that the area under the curve of irisin in non-diabetic groups and diabetic groups was 0.653 and 0.854 respectively. Conclusion：The irisin level may be related to obesity to a certain extent，but not related to T2DM，which has a certain diagnostic value for obesity in non-diabetic and diabetic populations.

关键词

肥胖2型糖尿病鸢尾素

Keywords

obesitytype 2 diabetes mellitusirisin

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Role of intestinal barrier in the occurrence and development of obesity related metabolic diseases

Changes of plasma proprotein convertase subtilisin/kexin type 9 levels in type 2 diabetes mellitus

Relationship between serum asprosin level and metabolic indices in patients with type 2 diabetes mellitus

Changes in plasma Apelin and Visfatin levels and relevant factors in the population with different glucose tolerance

A clinical study of cardiac autonomic neuropathy with retinopathy and nephropathy in patients with type 2 diabetes mellitus

Related Author

Wang Shan

Ni Yan

Fu Junfen

Zhang Xingyu

Yang Mei

Liang Dan

Wang Xiaoju

Zhang Hongmin

Related Institution

Department of Endocrinology，The Children's Hospital，Zhejiang University School of Medicine，National Clinical Research Center for Child Health

Department of Endocrinology，the First People’s Hospital of Liangjiang New District

Department of Endocrinology，Shanxi DAYI Hospital

Department of Graduate School， Shanxi Medical University

Department of Endocrinology，Taiyuan Central Hospital

⁰