Glomerular filtration rate（GFR） is an ideal indicator for estimating renal function. In the past，exogenous inulin or endoge－nous serum creatinine and creatinine-derived formula were used to estimate GFR，with many shortcomings. Therefore，a rapid and accurate way to assess GFR is in urgent need，avoiding the omission of early diagnosis of irreversible kidney injury. Recent studies have shown that new endogenous markers（β-trace-protein and β2-microglobulin，etc.） combination method，new exogenous bedside rapid determination of GFR technology（visible fluorescent injection），new prediction formula method（new type Xiangya equation，KeGFR equation，etc.），and metabolomics provide possibilities for rapid clinical evaluation of GFR. The article has briefly reviewed the traditional GFR assessment methods，discussed the improvement of traditional GFR assessment methods，and analyzed advantages and disadvantages of new GFR assessment technology，so as to promote the clinical transformation of new GFR technologies.