Clinical effect of tranexamic acid on mild and moderate traumatic brain injury in elderly patients

KUAI Guohu; LIU Jie; JIANG Wei

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Clinical effect of tranexamic acid on mild and moderate traumatic brain injury in elderly patients

更新时间：2022-06-24

- Clinical effect of tranexamic acid on mild and moderate traumatic brain injury in elderly patients
- null Issue 6, Pages: 541(2021)
- 作者机构：
  
  1. 武汉科技大学附属天佑医院神经外科,湖北,武汉,430064
  2. 大冶市人民医院神经外科,湖北,黄石,435100
  3. 华中科技大学同济医学院附属同济医院神经外科,湖北,武汉,430030
- 作者简介：
- 基金信息：
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KUAI Guohu, LIU Jie, JIANG Wei. Clinical effect of tranexamic acid on mild and moderate traumatic brain injury in elderly patients. [J]. null (6):541(2021)
DOI：

KUAI Guohu, LIU Jie, JIANG Wei. Clinical effect of tranexamic acid on mild and moderate traumatic brain injury in elderly patients. [J]. null (6):541(2021) DOI：

摘要

目的探讨氨甲环酸（TXA)治疗老年轻中度颅脑损伤（TBI）的临床疗效。方法选取30例老年轻中度TBI患者作为研究对象，按照随机数字表法分成TXA组及对照组，每组15例。TXA组在初始10 min内静脉注射0.9%氯化钠注射液100 mL配比的1 g TXA，然后在8 h内静脉滴注0.9%氯化钠注射液500 mL配比的1 g TXA维持；对照组输注同等量0.9%氯化钠注射液。评估2组颅内血肿变化、手术例数、入住神经外科重症监护病房（NICU)时间、住院时间、格拉斯哥预后量表(GOS)评分；观察TXA组使用TXA不良反应情况。结果 2组治疗前血肿量比较，差异无统计学意义（P＞0.05）；TXA组治疗后血肿量少于对照组（P＜0.05）。TXA组入住NICU时间及住院时间短于对照组（P＜0.05）。TXA组GOS评分优于对照组（P＜0.05）。2组手术例数方面比较，差异无统计学意义（P＞0.05）。TXA组未见明显不良反应发生。结论对于老年轻中度TBI患者，早期（3 h内）使用TXA不仅能够控制进展性颅内出血，缩短入住NICU时间及住院时间，还可以改善预后。

Abstract

关键词

老年人颅脑损伤氨甲环酸预后

Keywords

old peopletraumatic brain injurytranexamic acidprognosis

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