Correlation between Trx expression in colonic mucosa and pathogenesis of irritable bowel syndrome

ZHANG Chunyan; HUANG Xuefei; LI Congyong; SUN Gang; YANG Yunsheng

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Correlation between Trx expression in colonic mucosa and pathogenesis of irritable bowel syndrome

更新时间：2022-06-24

- Correlation between Trx expression in colonic mucosa and pathogenesis of irritable bowel syndrome
- null Issue 9, Pages: 685(2020)
- 作者机构：
  
  1. 解放军总医院第六医学中心干部消化科,北京,100048
  2. 解放军总医院第一医学中心消化病中心,北京,100853
- 作者简介：
- 基金信息：
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ZHANG Chunyan, HUANG Xuefei, LI Congyong, et al. Correlation between Trx expression in colonic mucosa and pathogenesis of irritable bowel syndrome. [J]. null (9):685(2020)
DOI：

ZHANG Chunyan, HUANG Xuefei, LI Congyong, et al. Correlation between Trx expression in colonic mucosa and pathogenesis of irritable bowel syndrome. [J]. null (9):685(2020) DOI：

摘要

目的观察硫氧还蛋白(Trx)在腹泻型肠易激综合征(IBS-D)和便秘型肠易激综合征(IBS-C)患者结肠黏膜中的表达情况

探讨肠易激综合征(IBS)的发病机制。方法选择2017年1月至2019年4月解放军总医院消化门诊收治的IBS-D、IBS-C患者各16例

分别设为IBS-D组和IBS-C组

另选择健康志愿者16例作为对照组

活检留取盲肠及乙状结肠黏膜组织

应用免疫组织化学染色分析。Western blot和荧光定量PCR法检测Trx及Trx mRNA表达情况。结果免疫组织化学染色显示

在正常结肠腺上皮细胞、隐窝上皮细胞、上皮基底膜和固有层间质细胞均可见Trx阳性表达。Western blot显示

Trx在IBS-D组和IBS-C组盲肠及乙状结肠的表达均明显高于对照组(P<0.05)。荧光定量PCR结果提示

与对照组比较

Trx mRNA在IBS-D组和IBS-C组盲肠黏膜的表达明显下调(P<0.05)

在IBS-D组和IBS-C组乙状结肠黏膜的表达明显上调(P<0.01)。结论 IBS发病机制可能与Trx相关的氧化应激、能量代谢异常及免疫稳态失衡相关。

Abstract

关键词

肠易激综合征硫氧还蛋白氧化应激免疫稳态代谢腹泻型便秘型

Keywords

irritable bowel syndromethioredoxinoxidative stressimmune homeostasismetabolismdiarrhea typeconstipation type

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