Expression of SIRT-1 and VEGF in gastric cancer and its clinical significance

ZHAO Jingya; LI Minghui; TIAN Yunxiao; FENG Yunzhang

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Expression of SIRT-1 and VEGF in gastric cancer and its clinical significance

更新时间：2022-06-24

- Expression of SIRT-1 and VEGF in gastric cancer and its clinical significance
- null Issue 1, Pages: 13(2020)
- 作者机构：
  
  1. 邯郸市中心医院病理科,河北,邯郸,056000
  2. 邯郸市中心医院普外二科,河北,邯郸,056000
- 作者简介：
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ZHAO Jingya, LI Minghui, TIAN Yunxiao, et al. Expression of SIRT-1 and VEGF in gastric cancer and its clinical significance. [J]. null (1):13(2020)
DOI：

ZHAO Jingya, LI Minghui, TIAN Yunxiao, et al. Expression of SIRT-1 and VEGF in gastric cancer and its clinical significance. [J]. null (1):13(2020) DOI：

摘要

目的探讨胃癌组织中沉默信息调节因子1（SIRT-1）和血管内皮生长因子（VEGF）的表达及临床意义。方法选取2016年6月至2018年6月本院胃癌患者120例，均接受胃癌手术切除术。采用免疫组化检测胃癌组织及其癌旁正常组织中SIRT-1、VEGF的表达。结果胃癌组织SIRT-1、VEGF表达阳性率明显高于癌旁正常组织，差异有统计学意义（P<0.05）；胃癌组织SIRT-1、VEGF的表达与TNM分期、浸润深度、浆膜受侵、淋巴结转移有关（P<0.05），与性别、年龄、肿瘤位置、分化程度、肿瘤直径无关（P>0.05）；胃癌组织SIRT-1与VEGF表达呈正相关（P<0.05）。结论胃癌组织中SIRT-1、VEGF呈高表达状态，且与胃癌的发生发展有关，可能共同促进了胃癌的生长、侵袭、转移等生物学行为。

Abstract

关键词

胃癌沉默信息调节因子1血管内皮生长因子表达

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