Effects of chrysin on viability，morphology and apoptosis of CAL-27 cells in tongue squamous cell carcinoma

LIN Chen-yang; XU Zhi-liang; ZENG Bin-hua; LUO Yan-rong

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Effects of chrysin on viability，morphology and apoptosis of CAL-27 cells in tongue squamous cell carcinoma

更新时间：2022-06-10

- Effects of chrysin on viability，morphology and apoptosis of CAL-27 cells in tongue squamous cell carcinoma
- null Issue 11, Pages: 939(2021)
- 作者机构：
  
  中国人民解放军联勤保障部队第九○九医院耳鼻喉颌面外科,福建,漳州,363000
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LIN Chen-yang, XU Zhi-liang, ZENG Bin-hua, et al. Effects of chrysin on viability，morphology and apoptosis of CAL-27 cells in tongue squamous cell carcinoma. [J]. null (11):939(2021)
DOI：

LIN Chen-yang, XU Zhi-liang, ZENG Bin-hua, et al. Effects of chrysin on viability，morphology and apoptosis of CAL-27 cells in tongue squamous cell carcinoma. [J]. null (11):939(2021) DOI：

摘要

目的探讨白杨素对舌鳞状细胞癌CAL-27细胞活力、形态、凋亡的影响。方法体外培养舌鳞状癌细胞CAL-27，空白对照组不给予任何药物，DMSO组以0.1％DMSO试剂处理，白杨素组给予不同浓度白杨素（1.0、2.5、5.0、10.0、15.0、20.0 μmol/L）处理。MMT法检测细胞活力，采用倒置显微镜观察细胞形态变化，TUNEL法检测细胞凋亡，Western blot印迹法检测凋亡蛋白（Bcl-2、Caspase-3）的表达情况。结果 CAL-27细胞经不同浓度白杨素处理24 h后，其细胞增殖活性被抑制；白杨素对CAL-27细胞形态存在显著影响，且凋亡小体数量增加；白杨素可促进CAL-27细胞凋亡（P<0.05）；白杨素可诱导Bcl-2表达显著下降及Caspase-3活性表达显著上升（P<0.05）。结论白杨素可以抑制舌鳞状细胞癌CAL-27细胞增长，降低细胞活力，调控细胞凋亡蛋白Bcl-2、Caspase-3活性的表达，促进细胞凋亡。

Abstract

关键词

舌鳞状细胞癌白杨素细胞活力细胞凋亡

Keywords

tongue squamous cell carcinomachrysincell viabilityapoptosis

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