Effect of sodium-glucose cotransporter-2 inhibitor on lipid metabolism in type 2 diabetes mellitus

Wang Cen; Li Ke

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Effect of sodium-glucose cotransporter-2 inhibitor on lipid metabolism in type 2 diabetes mellitus

更新时间：2023-12-22

- Effect of sodium-glucose cotransporter-2 inhibitor on lipid metabolism in type 2 diabetes mellitus
- Journal of Chongqing Medical University Vol. 45, Issue 12, Pages: 1713(2020)
- 作者机构：
  
  重庆医科大学附属第二医院内分泌与代谢病科,重庆,400010
- 作者简介：
- 基金信息：
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  CLC：
- Published：2020，
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Wang Cen, Li Ke. Effect of sodium-glucose cotransporter-2 inhibitor on lipid metabolism in type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 45(12):1713(2020)
DOI：

Wang Cen, Li Ke. Effect of sodium-glucose cotransporter-2 inhibitor on lipid metabolism in type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 45(12):1713(2020) DOI：

摘要

2型糖尿病（type 2 diabetes mellitus，T2DM）患者发生动脉粥样硬化性心血管疾病（atherosclerosis-associated cardiovas－cular disease，ASCVD）的危险相比非糖尿病患者明显升高。脂代谢异常与糖代谢异常合并，均为ASCVD的危险因素和发病机制。钠葡萄糖共同转运体-2抑制剂（sodium-glucose cotransporter-2 inhibitor，SGLT-2i）是一种通过肾脏排泄葡萄糖的新型降糖药。近年来多项大型临床研究表明SGLT-2i具有心血管和肾脏获益，但机制尚不明确。本文综述了SGLT-2i对T2DM中的脂代谢影响，分析其与上述保护作用之间的可能关系。

Abstract

The risk of arteriosclerotic cardiovascular disease（ASCVD） in patients with type 2 diabetes mellitus（T2DM） is significantly higher than that in non-diabetic patients. Abnormal lipid metabolism and abnormal glucose metabolism are risk factors and pathogen－esis of ASCVD. The sodium-glucose cotransporter-2 inhibitor（SGLT-2i） is a new type of hypoglycemic agent excreting glucose via kidneys. Recent large clinical trials have shown that SGLT-2i shows significant cardiovascular and kidney benefits，but its mechanism remains unclear. This article reviewed effects of SGLT-2 inhibition on lipid metabolism in T2DM and analyzed its possible relation－ship with above protective effects.

关键词

钠葡萄糖共同转运体-2抑制剂脂代谢2型糖尿病动脉粥样硬化相关性心血管疾病

Keywords

sodium-glucose cotransporter-2 inhibitorlipid metabolismtype 2 diabetes mellitusatherosclerosis-associated cardio－vascular disease

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Related Institution

Department of Endocrinology,The First Affiliated Hospital of Chongqing Medical University

重庆医科大学临床学院检验科

Department of Clinical Laboratory, College of Clinical Medicine, Chongqing Medical University

Department of Endocrinology，The First People’s Hospital of Yunnan Province/Affiliated Hospital of Kunming University of Science and Technology

The First College of Clinical Medicine，Yunnan University of Chinese Medicine

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