Objective：To explore the association of triglycerides total cholesterol body weight index（TCBI） with coronary artery disease（CAD）and coronary artery calcified plaque burden. Methods：A total of 561 inpatients meeting the inclusion criteria with suspected stable CAD were consecutively enrolled from September 2015 to June 2017 in the Affiliated Hospital of Chengde Medical University. All of them were divided into the CAD group（n=402） and the non-CAD group（n=159） according to coronary computed tomographic angiography results. We collected clinical data，measured coronary artery calcification（CAC），and assessed CAC scores of all the subjects. A binary logistic multivariate regression model was established on the risk factors of CAD，CAC，and CAD with CAC. Results：The area under the curve of TCBI≥1 818.7 was 0.557（P=0.036），and that of TCBI≥1 818.7 combined with CAD classic risk factors，such as male，smoking，hypertension，type 2 diabetes，and ischemic stroke，was 0.726（P＜0.001）. The prevalence of TCBI increased in the CAD group was higher than that in the non-CAD group（P=0.008）. The prevalence of CAD，type 2 diabetes，dyslipi－demia，and CAC incidence in the high TCBI group was higher than that in the low TCBI group（all P<0.05）. TCBI was positively correlated with epicardial adipose tissue volume，pericardial adipose tissue volume，triglyceride-glucose index，and plasma atheroscle－rosis index（all P<0.05）. Besides classic CAD risk factors，TCBI ≥1 818.7 was a newly discovered independent risk factor for CAD，CAC，and CAD with CAC（all P<0.05）. Conclusion：TCBI≥1 818.7 is an independent risk factor for CAD，CAC，and CAD with CAC，which may be a novel marker for the diagnosis and evaluation of CAD.