A large number of patients with coronavirus disease 2019（COVID-19） have been found in Wuhan，Hubei Province，and similar cases have been found in other parts of China with the spread of the disease. Therefore，medical teams from all over the country have rushed into Hubei to support treating the disease. On February 8，2020，the third anti-epidemic medical aid team to Hubei from West China Hospital，Sichuan University was stationed in the Eastern Hospital of Wuhan University People’s Hospital. After optimiz－ing the management system and procedure which are related with nosocomial infection，there is no hospital infection. The following is a summary of the resident prevention and control experience of our medical aid team from aspects of ward responsibility system of in－fection control team，ward regional planning，process management，personnel behavior management，disinfection and isolation，etc.，providing a reference for the precise prevention and control of outbreak of infectious diseases.