Objective：To explore the nursing emergency strategy of district and county secondary hospitals in non-centralized coron－avirus disease 2019（COVID-19） treatment center in order to provide reasonable nursing emergency management reference for similar hospitals. Methods：During the diagnosis and treatment of COVID-19 in our hospital，nursing emergency strategies were timely imple－mented according to reasonable management of nursing human resource，enhancing nursing staff’s new knowledge and skills training，implementing scientific nursing quality control management，rational deployment of emergency protection materials，and providing personalized COVID-19 health education. Results：Prevention and control work of COVID-19 on nursing was carried out effectively and there was no record about misdiagnosis of infected patients，no infection of suspected patients and no infection of medical staff. Conclusion：Nursing managers should comprehensively combine responsibilities of non-centralized hospitals and limited nursing re－sources of district and county secondary hospitals，make all-round and multidimensional rational decisions，and adopt suitable nursing emergency strategies in accordance with regional conditions，so as to ensure the successful implementation of COVID-19 nursing pre－vention and control work.