Objective：To investigate the expression and prognostic significance of tumor abnormal protein（TAP） on peripheral blood in colorectal cancer patients. Methods：A total of 237 colorectal cancer patients from June 2014 to December 2016 were enrolled and followed up. The pre-treatment TAP expression in peripheral blood was detected，the chi-square test was used to analyze the correla－tion between TAP expression and clinical features of colorectal cancer patients，the expression data of traditional tumor markers CEA and CA19-9 in peripheral blood of patients were collected，and the relationship among TAP expression，CEA and CA19-9 were ana－lyzed. Kaplan-Meier survival curve and univariate and multivariate Cox regression were used to analyze the relationship between TAP expression and prognosis in colorectal cancer patients. Results：Among 237 colorectal cancer patients，59.92% patients had positive expression of TAP in peripheral blood. Peripheral blood TAP expression was associated with tumor cell differentiation，depth of myome－trial invasion，lymph node metastasis，and tumor stage（Dukes stage），with statistically significant difference（P<0.05）. After multivari－ate Cox regression’s correction of age，gender，cell differentiation，invasion degree，lymph node metastasis，Dukes stage，CEA expres－sion and CA19-9 expression，TAP expression in the peripheral blood was significantly associated with overall survival time of colorectal cancer（HR=2.511，95%CI=1.494-4.221，P<0.05）. In addition，the risk ratio of peripheral blood TAP for predicting survival outcome in colorectal cancer patients was higher than that of CEA and CA19-9. Conclusion：The expression of TAP in peripheral blood of colorectal cancer patients is related to the malignant degree of cancer，and can be used as an independent prognostic indicator for colorectal cancer，with predicating function for patients’ overall survival time.