Potential function and significance of autophagy on the immunosuppression of severe acute pancreatitis

Zhang Ling; Si Fei; Xiao Danyang; Zhao Jing; Zhang Haidan; Li Peiwu

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Potential function and significance of autophagy on the immunosuppression of severe acute pancreatitis

更新时间：2023-12-22

- Potential function and significance of autophagy on the immunosuppression of severe acute pancreatitis
- Journal of Chongqing Medical University Vol. 45, Issue 9, Pages: 1362(2020)
- 作者机构：
  
  兰州大学第二医院急救中心 & 急危重症科,兰州,730000
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2020，
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Zhang Ling, Si Fei, Xiao Danyang, et al. Potential function and significance of autophagy on the immunosuppression of severe acute pancreatitis. [J]. Journal of Chongqing Medical University 45(9):1362(2020)
DOI：

Zhang Ling, Si Fei, Xiao Danyang, et al. Potential function and significance of autophagy on the immunosuppression of severe acute pancreatitis. [J]. Journal of Chongqing Medical University 45(9):1362(2020) DOI：

摘要

重症胰腺炎（sever acute pancreatitis，SAP）是常见的腹部急症之一，有病情重且病死率高、预后差的特点。免疫抑制在SAP病情发生发展过程中起推动作用。自噬作为一种细胞活动，不仅参与SAP期间胰蛋白酶原的活化，还对机体免疫系统具有明显影响。SAP不同阶段，免疫细胞和自噬均出现不同的状态，本文就自噬在SAP免疫抑制中的潜在作用及意义作一综述。

Abstract

Severe acute pancreatitis（SAP） is one of the common abdominal emergencies，which is often characterized by severe con－dition，high mortality and poor prognosis. However，immunosuppression plays a promoting role in SAP progression. Autophagy，as a cel－lular activity，not only participates in the activation of trypsinogen during SAP，but also significantly influences the immune system. In different stages of SAP，immune cells and autophagy demonstrates different forms. This paper reviewed the potential function and sig－nificance of autophagy in SAP immunosuppression.

关键词

自噬重症胰腺炎免疫抑制

Keywords

autophagysevere acute pancreatitisimmunosuppression腹水前列腺素E2在诊断自发性腹膜炎和预测住院死亡率中的价值研究

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