Objective：To analyze the mood disorder and its influencing factors in diabetic nephropathy patients with maintenance hemodialysis，so as to provide evidence for the clinical treatment and psychological counseling of patients. Methods：A total of 150 patients with diabetic nephropathy received maintenance hemodialysis in our hospital were selected，and 150 non-diabetic nephropa－thy patients with matching age and gender received hemodialysis were selected. Clinical data and biomedical data were collected. Zung self rating anxiety scale（SAS） and Zung depression self rating scale（SDS） were used to survey mood disorders in two groups，to analyze the related factors of mood disorders in diabetic nephropathy patients with hemodialysis. Results：There was no significant difference in age and gender between two groups. Among the 150 diabetic nephropathy patients with hemodialysis，the incidence of anxiety and depression and sleeping scores were higher than those in non-diabetic nephropathy patients，with statistically significant differences（P=0.05）. Among diabetic nephropathy patients with hemodialysis，the number of women with mood disorders was signif－icantly higher than that without mood disorders（P=0.000）；but differences in hemoglobin，serum albumin，serum calcium，serum phosphorus，iPTH，single compartment urea clearance rate（spKt/V） level of diabetic nephropathy patients in the normal group and the depression group had no statistical significance（P>0.05）. Cardiovascular and cerebrovascular complications，restless legs，skin itching，sleep disorder and bone pain in the depression group were significantly higher than those in the normal group，with statistically signif－icantly differences（P<0.05）. Conclusion：Patients with diabetic nephropathy are prone to have emotional disorders during hemodialysis，and female，cardiovascular disease，cerebrovascular disease，bone pain and other complications as well as low social support are independent risk factors for mood disorders in diabetic nephropathy patients with hemodialysis.