Objective：To investigate the application of autologous blood transfusion on surgery of uncomplex congenital heart disease in children for decreasing the need for clinical blood transfusion. Methods：A total of 110 patients with uncomplex congenital heart disease who underwent surgical treatment in our hospital from January 2019 to June 2019 were selected and divided into two groups：38 patients used autologous blood transfusion as the case group and 72 patients not used autologous blood transfusion as the control group. The number of intra-and-post-operation blood transfusions was collected and analyzed in two groups. Results：Compared with the control group，the number of intra-and-post-operation blood transfusions in the case group was significantly reduced（P=0.019，P=0.000）；the number of allogeneic red blood cell（RBC） and fresh frozen plasma transfusions during operation in the case group were significantly reduced（P=0.006，P=0.016）；the number of allogeneic RBC transfusion after surgery in the case group was significantly reduced（P=0.001）；levels of hemoglobin（Hb） and hematocrit（Hct） after surgery in the case group were higher（P=0.001，P=0.010）. Conclusion：The use of autologous blood transfusion during the operation can significantly reduce intraoperative and postopera－tive allogeneic blood transfusions in the children with uncom－plex congenital heart disease requiring surgical treatment，which is worth clinical promotion.