Objective：To evaluate the effect of continuous nursing mode based on network and telephone follow-up on the compliance of colonoscopy screening in high-risk populations with colorectal cancer. Methods：A total of 300 patients with high-risk colorectal cancer which were evaluated by risk evaluation model from January 2017 to November 2017 were selected and were randomly divided into the intervention group and the control group，with 150 people in each group. Basic information were collected and patients in both groups received routine health education related with colorectal cancer. In addition，patients in the intervention group received the continuous nursing intervention conducting through WeChat and telephone. Colonoscopy screening in two groups were observed during the 3-month and 6-month follow-up period，and differences were compared by using t-test，chi-square analysis and logistic regression analysis. Results：During the 6-month follow-up，266 patients were completely followed up，including 137 in the intervention group and 129 in the control group. According to the t-test or chi-square analysis showed that baseline data between the intervention group and the control group had no statistically significant difference（P>0.05）. The compliance of colorectal screening at the 3rd and 6th month in the intervention group was higher than that in the control group，and the difference was statistically significant （P<0.05）. Multivariate logistic regression analysis of the effect of the 3-month intervention showed that continuous nursing inter－vention based on network and telephone follow-up was the in－dependent factor influencing high-risk populations with col－orectal cancer to accept colonoscopy screening（RR=2.697，95%CI=1.307-5.567；P<0.05）. Multivariate logistic regression analysis of the effect of the 6-month intervention also showed that continuous nursing intervention based on network and telephone follow-up was the independent factor influencing high-risk populations with colorectal cancer to accept colonoscopy screening（RR=2.574，95%CI=1.396-4.749；P<0.05）. Conclusion：Continuous nursing intervention based on network and telephone follow-up can improve the colonoscopy screening rate in high-risk populations with colorectal cancer，with a certain promoted value for early detection，early diagnosis and improving diagnosis.