Objective：To evaluate the relationship between soluble ST2（sST2） and global registry of acute coronary events（GRACE） score in patients with non-ST-segment elevation acute coronary syndrome（NSTE-ACS），so as to provide early risk assessment in the early stage and subsequent clinical treatment for patients with acute coronary syndrome（ACS）. Methods：A total of 121 patients with NSTE-ACS who made a definite diagnosis were selected and were divided into the non-ST-segment elevation myocardial infarction （NSTEMI） group and the unstable angina pectoris（UA） group. After admission，patients’ GRACE score was obtained and patients were grouped. Ulnar vein blood was collected on an empty stomach at the second day. The plasma expression level of soluble ST2 was detected with ELISA method. And 60 patients with stable coronary heart disease were taken as the control group. Results：Compared with the control group，the level of sST2 in the low-risk，medium-risk and high-risk groups showed an upward trend and the level of sST2 in the high-risk group showed a significant increase，with statistically significant differences（P<0.05）；the sST2 level was increased with the increasing degree of GRACE risk，with statistically significant difference（P<0.05）. Results of correlation analysis showed that sST2 had a positive correlation with GRACE scores（r=0.444，P<0.01）；the level of sST2 was positively associated with neutrophil-to-lymphocyte ratio（NLR）（r=0.442，P=0.000，P<0.01）. The area under ROC curve of ST2 diagnosing ACS was 0.788，with the optimal critical point of 44.5 ng/mL，sensitivity of 66.3% and specificity of 86.4%. Conclusion：The level of plasma sST2 in patients with NSTE-ACS is significantly increased and is closely related. Combination of sST2 and GRACE score has vital clinical value on early risk classification，prognosis evaluation and selecting treat－ment.