Research progress on the mechanisms underlying the effects of overweight/obesity on recurrent spontaneous abortion

Bai Rong; Jia Dan; Song Yuqiang; Yao Ding’ai; Wang Shimeng; Song Qingxia; Feng Xiaoling

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Research progress on the mechanisms underlying the effects of overweight/obesity on recurrent spontaneous abortion

更新时间：2026-10-27

- Research progress on the mechanisms underlying the effects of overweight/obesity on recurrent spontaneous abortion
- Journal of Chongqing Medical University Pages: 1-7(2026)
- 作者机构：
  
  1.黑龙江中医药大学研究生院，哈尔滨 150040
  2.南京中医药大学附属苏州市中医医院妇科，苏州 215000
  3.首都医科大学附属北京中医医院针灸中心，北京 100010
  4.黑龙江中医药大学附属第一医院妇科二科，哈尔滨 150040
- 作者简介：
- 基金信息：
- DOI：
  CLC： R714
- Received：05 June 2026，
  
  Revised：2026-10-19，
  
  Accepted：22 October 2026，
  
  Published：27 October 2026
- 稿件说明：
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Bai Rong,Jia Dan,Song Yuqiang,et al.Research progress on the mechanisms underlying the effects of overweight/obesity on recurrent spontaneous abortion[J].Journal of Chongqing Medical University,
DOI：

Bai Rong,Jia Dan,Song Yuqiang,et al.Research progress on the mechanisms underlying the effects of overweight/obesity on recurrent spontaneous abortion[J].Journal of Chongqing Medical University, DOI：10.13406/j.cnki.cyxb..

摘要

随着全球超重/肥胖患病率逐年攀升，育龄期肥胖女性约占全球肥胖总人数的40%，肥胖相关复发性流产（recurrent spontaneous abortion，RSA）已成为生殖医学研究热点。超重/肥胖可能通过卵母细胞质量与胚胎质量受损、子宫内膜容受性异常及蜕膜化异常、母胎界面免疫失衡等机制影响RSA的发生发展。生活方式干预、药物治疗及减重手术等管理策略，有望改善再次妊娠结局。本文为肥胖相关RSA的孕前诊疗与规范化体质量管理提供理论依据。

Abstract

As the global prevalence of overweight and obesity increases year by year，women of reproductive age with obesity account for approximately 40% of the global population with obesity. Obesity-related recurrent spontaneous abortion （RSA） has become a hot topic in reproductive medicine research. Overweight/obesity may contribute to the development and progression of RSA through several mechanisms，including impaired oocyte and embryo quality，abnormal endometrial receptivity and decidualization，and immune imbalance at the maternal-fetal interface. Management strategies，including lifestyle interventions，pharmacotherapy，and bariatric surgery，may help improve the outcomes of subsequent pregnancies. This article provides a theoretical basis for the preconception diagnosis and treatment of obesity-related RSA and for standardized weight management in the relevant population.

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references

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