Objective:To investigate the effect of medroxyprogesterone acetate for ovulation induction on the outcome of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer（IVF/ICSI-ET）in patients with diminished ovarian reserve（DOR）.Methods:A total of 72 patients with DOR who underwent IVF/ICSI-ET to promote pregnancy were divided into control group and observation group.The patients in the control group received the ultra-short protocol

and those in the observation group received medroxyprogesterone acetate combined with human menopausal gonadotropin（HMG）for ovulation induction.The change in the level of luteinizing hormone（LH）during ovulation induction was observed

and the two groups were compared in terms of the number of retrieved oocytes

the number of mature oocytes

and the number of high-quality embryos.Results:No LH surges were detected during ovulation induction in the observation group

and there were no significant differences between the observation group and the control group in the number of retrieved oocytes（3.31 ± 1.26 vs 3.11 ± 1.21

P > 0.05）.The number of MⅡ oocytes（3.17 ± 1.16 vs 2.97 ± 1.16

P > 0.05）

and the number of high-quality embryos on day 3（2.25 ± 0.87 vs 2.14 ± 1.02

P > 0.05）.Compared with the control group

the observation group had a significantly lower level of LH on MC（7 ～ 9）day

MC（10 ～ 12）day

and trigger day（P < 0.05）.There was no significant difference in the level of progesterone between the two groups（P > 0.05）.Conclusion:The use of medroxyprogesterone acetate is an effective method to inhibit premature LH surges

and its combination with HMG can achieve a good effect of ovulation induction in patients with DOR and is thus an alternative treatment method.