1.江西中医药大学中医基础理论分化发展研究中心/江西省中医病因生物学重点实验室,南昌 330004
2.江西中医药大学附属医院,南昌 330004
Received:26 March 2026,
Revised:2026-06-01,
Accepted:03 June 2026,
Published:01 July 2026
移动端阅览
Han Weiwei,Nie Peng,Chen Limei,et al.Potential mechanisms and prospects of yin-nourishing traditional Chinese medicines in preventing and treating lung cancer based on aquaporins[J].Journal of Chongqing Medical University,
Han Weiwei,Nie Peng,Chen Limei,et al.Potential mechanisms and prospects of yin-nourishing traditional Chinese medicines in preventing and treating lung cancer based on aquaporins[J].Journal of Chongqing Medical University, DOI:10.13406/j.cnki.cyxb..
肺癌发病机制复杂,中医“养阴润肺”的治法在改善肺癌患者预后方面具有独特优势。水通道蛋白(aquaporins,AQPs)作为调控水液转运的关键跨膜蛋白,在肺癌组织中的异常表达,与肿瘤增殖、侵袭及耐药密切相关。本文基于“阴液亏虚-痰瘀互结”的核心病机,系统梳理了中医对肺癌的传统认知与阴虚致瘤的理论溯源,阐明阴虚病机与AQPs异常之间的关联;总结了沙参麦冬汤、百合固金汤等经典滋阴复方、单味滋阴中药及活性成分防治肺癌的作用机制,重点梳理其调控AQPs表达的现有证据与潜在通路;从抑制上皮-间质转化(epithelial-mesenchymal transition,EMT)、增强化疗敏感性等角度,探讨滋阴中药“增液化痰-解毒散结”的科学内涵,以期为滋阴中药防治肺癌的临床应用提供理论依据。
The pathogenesis of lung cancer is complex. The treatment principle of “nourishing yin and moistening lung” in traditional Chinese medicine has unique advantages in improving the prognosis of patients with lung cancer. Aquaporins(AQPs),as key transmembrane proteins regulating water transport,are abnormally expressed in lung cancer tissues and are closely related to tumor proliferation,invasion and drug resistance. Based on the core pathogenesis of “yin fluid deficiency-intermingled phlegm and blood stasis”,this paper systematically reviews the traditional cognition of lung cancer in traditional Chinese medicine and the theoretical origin of yin deficiency-induced tumor,and clarifies the correlation between yin deficiency pathogenesis and AQPs abnormality. The mechanism of action of Shashen Maidong Decoction,Baihe Gujin Decoction,and other classical yin-nourishing compounds,single yin-nourishing Chinese medicine and active ingredients in the prevention and treatment of lung cancer is summarized,focusing on the existing evidence and potential pathways of their regulation of AQPs expression. From the perspective of inhibiting epithelial-mesenchymal transition and enhancing chemotherapy sensitivity,the scientific connotation of yin-nourishing traditional Chinese medicine “increasing fluid and resolving phlegm-detoxifying and dissipating nodules” is discussed in order to provide a theoretical basis for the clinical application of yin-nourishing traditional Chinese medicine in the prevention and treatment of lung cancer.
Siegel RL , Miller KD , Jemal A . Cancer statistics,2020 [J ] . CA Cancer J Clin , 2020 , 70 ( 1 ): 7 - 30 .
何伶文 , 严小军 , 刘红宁 . 肿瘤病因病机总结及其阴虚病机初探 [J ] . 辽宁中医杂志 , 2017 ( 5 ): 934 - 936 .
He LW , Yan XJ , Liu HN . Tumor etiology and pathogenesis summary and preliminary study of Yin-deficiency [J ] . Liaoning J Tradit Chin Med , 2017 ( 5 ): 934 - 936 .
刘福栋 , 姜晓晨 , 花宝金 , 等 . 全国名中医朴炳奎“扶正培本”防治肺癌经验探析 [J ] . 北京中医药 , 2022 , 41 ( 5 ): 490 - 493 .
Liu FD , Jiang XC , Hua BJ , et al . PIAO Bing-Kui’s experience in preventing and treating lung cancer by “strengthening body resistance and strengthening body constitution” [J ] . Beijing J Tradit Chin Med , 2022 , 41 ( 5 ): 490 - 493 .
汪 馨 , 彭海燕 . “三位一体”辨治肺癌探析 [J ] . 江苏中医药 , 2018 , 50 ( 3 ): 21 - 24 .
Wang X , Peng HY . Analysis of “trinity” in differentiation and treatment of lung cancer [J ] . Jiangsu J Tradit Chin Med , 2018 , 50 ( 3 ): 21 - 24 .
于双江 , 张慧婷 , 王雪玭 , 等 . 原发性支气管肺癌的中医证候要素分布规律研究 [J ] . 湖南中医杂志 , 2020 , 36 ( 8 ): 151 - 152,159 .
Yu SJ , Zhang HT , Wang XP , et al . Study on the distribution law of TCM syndrome elements in primary bronchial lung cancer [J ] . Hunan J Tradit Chin Med , 2020 , 36 ( 8 ): 151 - 152,159 .
刘建秋 , 吉俊嵘 , 蒋鹏娜 . 肺癌的中医病因病机研究进展 [J ] . 中华中医药学刊 , 2008 , 26 ( 5 ): 912 - 913 .
Liu JQ , Ji JR , Jiang PN . Research progress on lung cancer etiopathogensis and pathogenesis of traditional Chinese medicine [J ] . Chin Arch Tradit Chin Med , 2008 , 26 ( 5 ): 912 - 913 .
陶李蕙苹 , 赖岳阳 , 李 柳 , 等 . 基于癌毒病机理论辨治肺癌探讨 [J ] . 中华中医药杂志 , 2023 , 38 ( 1 ): 214 - 217 .
Tao L , Lai YY , Li L , et al . Differentiation and treatment of lung cancer based on pathogenesis theory of cancer toxin [J ] . China J Tradit Chin Med Pharm , 2023 , 38 ( 1 ): 214 - 217 .
翟韵怡 , 高静东 . 养阴解毒法治疗肺癌的临床研究进展 [J ] . 中国医学创新 , 2024 , 21 ( 18 ): 180 - 184 .
Zhai YY , Gao JD . Clinical research progress in the treatment of lung cancer with nourishing Yin and detoxifying method [J ] . Med Innov China , 2024 , 21 ( 18 ): 180 - 184 .
王珊珊 , 郭 茗 , 朱 垚 , 等 . 国医大师周仲瑛教授辨治肺癌经验 [J ] . 中华中医药杂志 , 2015 , 30 ( 12 ): 4332 - 4335 .
Wang SS , Guo M , Zhu Y , et al . TCM master ZHOU Zhong-Ying’s experience in differentiating and treating lung cancer [J ] . China J Tradit Chin Med Pharm , 2015 , 30 ( 12 ): 4332 - 4335 .
林 亮 , 徐光星 . 徐光星教授依主次病机从“燥”论治肺癌经验 [J ] . 浙江中医药大学学报 , 2023 , 47 ( 8 ): 852 - 856,862 .
Lin L , Xu GX . Professor XU guangxing’s experience in treating lung cancer from the perspective of“dryness”Based on priorities pathogenesis [J ] . J Zhejiang Chin Med Univ , 2023 , 47 ( 8 ): 852 - 856,862 .
郑洪新 . 中医基础理论专论 [M ] . 北京 : 中国中医药出版社 , 2016 .
Zheng HX . Monograph on basic theory of traditional Chinese medicine [M ] . Beijing : China Press of Traditional Chinese Medicine , 2016 .
张 宁 , 刘树民 , 于栋华 , 等 . 水通道蛋白与中医学水液代谢的相关性探索 [J ] . 时珍国医国药 , 2017 , 28 ( 5 ): 1170 - 1172 .
Zhang N , Liu SM , Yu DH , et al . Correlation between aquaporin and water-liquid metabolism in traditional Chinese medicine [J ] . Lishizhen Med Mater Med Res , 2017 , 28 ( 5 ): 1170 - 1172 .
崔荣兴 . 阴虚津亏模型小鼠唾液腺水通道蛋白AQP1、AQP5的表达及意义 [D ] . 南京 : 南京中医药大学 , 2021 .
Cui RX . Expression and significance of aquaporins AQP1 and AQP5 in salivary glands of mice with Yin-deficiency and fluid consumption [D ] . Nanjing : Nanjing University of Chinese Medicine , 2021 .
Yadav E , Yadav N , Hus A , et al . Aquaporins in lung health and disease: Emerging roles,regulation,and clinical implications [J ] . Respir Med , 2020 , 174 : 106193 .
柏正平 , 刘 雨 , 谭小宁 , 等 . 金水六君煎及其拆方含药血清对A549细胞中黏蛋白MUC5AC及水通道蛋白AQP5表达的影响 [J ] . 湖南中医药大学学报 , 2019 , 39 ( 3 ): 320 - 325 .
Bai ZP , Liu Y , Tan XN , et al . Effects of serum containing Jinshui Liujun decoction and its components on the expression of mucin MUC5AC and aquaporin AQP5 in A549 cell mucus hypersecretion model [J ] . J Tradit Chin Med Univ Hunan , 2019 , 39 ( 3 ): 320 - 325 .
李 华 . 肺癌的中医辨治体会 [J ] . 光明中医 , 2002 , 17 ( 2 ): 20 - 22 .
Li H . Experience of TCM differentiation and treatment of lung cancer [J ] . J Tradit Chin Med , 2002 , 17 ( 2 ): 20 - 22 .
张 胤 , 李 忠 , 张 彤 , 等 . 李忠教授基于“癌状态论”从复法大方论治肺癌的临证经验 [J ] . 中国医药导报 , 2025 , 22 ( 12 ): 154 - 158 .
Zhang Y , Li Z , Zhang T , et al . Professor Li Zhong’s clinical experience in the treatment of lung cancer with complex and generous methods based on “cancer state theory” [J ] . China Med Her , 2025 , 22 ( 12 ): 154 - 158 .
刘丽坤 , 李宜放 , 王晞星 . 肺癌的病机及治法探讨 [J ] . 中国中医基础医学杂志 , 2004 , 10 ( 5 ): 75 - 76,79 .
Liu LK , Li YF , Wang XX . Exploration of the pathogenesis and therapeutic methods of lung cancer [J ] . Chin J Basic Med Tradit Chin Med , 2004 , 10 ( 5 ): 75 - 76,79 .
Laguna JC , García-Pardo M , Alessi J , et al . Geographic differences in lung cancer: focus on carcinogens,genetic predisposition,and molecular epidemiology [J ] . Ther Adv Med Oncol , 2024 , 16 : 17588359241231260 .
Yoo J , Lee Y , Park Y , et al . Update in association between lung cancer and air pollution [J ] . Tuberc Respir Dis , 2025 , 88 ( 2 ): 228 - 236 .
宋凤丽 , 李 仝 . 李佩文治疗原发性肺癌经验 [J ] . 中华中医药杂志 , 2019 , 34 ( 10 ): 4637 - 4639 .
Song FL , Li T . LI Pei-Wen’s experience in the treatment of primary lung cancer [J ] . China J Tradit Chin Med Pharm , 2019 , 34 ( 10 ): 4637 - 4639 .
郑淑君 , 王辛秋 , 贾喜花 , 等 . 国医大师晁恩祥辨治肺癌经验 [J ] . 中华中医药杂志 , 2022 , 37 ( 7 ): 3855 - 3857 .
Zheng SJ , Wang XQ , Jia XH , et al . TCM master CHAO En-Xiang’s experience in the treatment of lung cancer [J ] . China J Tradit Chin Med Pharm , 2022 , 37 ( 7 ): 3855 - 3857 .
孙雨昕 , 祝盼盼 , 卢梓铤 , 等 . 国医大师洪广祥治疗肺癌晚期学术思想撷菁 [J ] . 中医药通报 , 2024 , 23 ( 5 ): 4 - 6,29 .
Sun YX , Zhu PP , Lu ZT , et al . Summary of academic thoughts on the treatment of advanced lung cancer by great TCM master HONG Guangxiang [J ] . Tradit Chin Med J , 2024 , 23 ( 5 ): 4 - 6,29 .
姚 彦 , 郭春霞 , 郭 莉 , 等 . 北沙参对肺癌大鼠PI3K/Akt信号通路及免疫炎症反应的影响 [J ] . 现代生物医学进展 , 2023 , 23 ( 11 ): 2035 - 2039 .
Yao Y , Guo CX , Guo L , et al . Effects of Radix glehniae on PI3K/Akt signal pathwayand immune inflammatory response in lung cancer rats [J ] . Prog Mod Biomed , 2023 , 23 ( 11 ): 2035 - 2039 .
王振飞 , 刘 丽 , 梁 琳 , 等 . 北沙参抑制肺癌细胞迁移侵袭能力的研究 [J ] . 中医药通报 , 2018 , 17 ( 3 ): 62 - 64,72 .
Wang ZF , Liu L , Liang L , et al . Inhibitory effect of Radix glehniae extract on the migration and invasion abilities of lung cancer cells [J ] . Tradit Chin Med J , 2018 , 17 ( 3 ): 62 - 64,72 .
罗林明 , 覃 丽 , 詹济华 , 等 . 百合总皂苷对肺癌细胞增殖、凋亡及侵袭转移的作用及其初步机制研究 [J ] . 中国中药杂志 , 2018 , 43 ( 22 ): 4498 - 4505 .
Luo LM , Qin L , Zhan JH , et al . Study on effects of total saponins from Lilii Bulbus on proliferation,apoptosis,invasion and metastasis of lung cancer cells and its preliminary mechanism [J ] . China J Chin Mater Med , 2018 , 43 ( 22 ): 4498 - 4505 .
王依蕾 , 洪 婷 , 曾海荣 , 等 . 麦冬皂苷B促进细胞铁死亡抑制非小细胞肺癌A549细胞增殖的机制 [J ] . 中国医院药学杂志 , 2022 , 42 ( 19 ): 1983 - 1989 .
Wang YL , Hong T , Zeng HR , et al . Mechanism of ophiopogonin B inhibiting the proliferation of non-small cell lung cancer A549 cells by promoting cell ferroptosis [J ] . Chin J Hosp Pharm , 2022 , 42 ( 19 ): 1983 - 1989 .
Chen MJ , Hu C , Guo YY , et al . Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway [J ] . Oncol Rep , 2018 : 52 ( 3 ): 115 .
Lee JH , Kim C , Lee SG , et al . Ophiopogonin D,a steroidal glycoside abrogates STAT3 signaling cascade and exhibits anti-cancer activity by causing GSH/GSSG imbalance in lung carcinoma [J ] . Cancers , 2018 , 10 ( 11 ): 427 .
臧海洋 , 杨君伶 , 陈秋峰 , 等 . 山麦冬皂苷B调节DAMPs释放诱导免疫源性细胞死亡的抗肿瘤机制研究 [J ] . 辽宁中医杂志 , 2024 , 51 ( 11 ): 150 - 153 , 2 - 4 .
Zang HY , Yang JL , Chen QF , et al . Antitumor effect of spicatoside B based on regulating DAMPs release to induce immunogenic cell death [J ] . Liaoning J Tradit Chin Med , 2024 , 51 ( 11 ): 150 - 153 , 2 - 4 .
Sheng HX , Lv W , Zhu LH , et al . Liriopesides B induces apoptosis and cell cycle arrest in human non-small cell lung cancer cells [J ] . Int J Mol Med , 2020 , 46 ( 3 ): 1039 - 1050 .
Li HY , Sun L , de Carvalho EL , et al . DT-13,a saponin monomer of dwarf lilyturf Tuber ,induces autophagy and potentiates anti-cancer effect of nutrient deprivation [J ] . Eur J Pharmacol , 2016 , 781 : 164 - 172 .
张金萍 , 葛基春 , 李强明 , 等 . 霍山石斛多糖对Lewis肺癌荷瘤小鼠肿瘤生长的抑制作用 [J ] . 现代食品科技 , 2023 , 39 ( 7 ): 7 - 15 .
Zhang JP , Ge JC , Li QM , et al . The inhibitory effects of Dendrobium huoshanense polysaccharides on tumor growth in lewis lung carcinoma-bearing mice [J ] . Mod Food Sci Technol , 2023 , 39 ( 7 ): 7 - 15 .
刘 杰 , 刘绍欢 , 陈岩勤 , 等 . 基于糖酵解的金钗石斛乙醇提取物抗肺癌的药理机制研究 [J ] . 中国新药与临床杂志 , 2022 , 41 ( 9 ): 566 - 572 .
Liu J , Liu SH , Chen YQ , et al . Pharmacological mechanism of anti-lung cancer of Dendrobium nobile ethanol extract through glycolysis [J ] . Chin J New Drugs Clin Remedies , 2022 , 41 ( 9 ): 566 - 572 .
Chang TM , Chi MC , Chiang YC , et al . Promotion of ROS-mediated apoptosis,G2/M arrest,and autophagy by naringenin in non-small cell lung cancer [J ] . Int J Biol Sci , 2024 , 20 ( 3 ): 1093 - 1109 .
庞 晨 , 张锡流 , 张秀玲 , 等 . 鲜铁皮石斛对肺腺癌裸鼠移植瘤中自噬及抑癌基因表达的影响 [J ] . 医药导报 , 2021 , 40 ( 2 ): 163 - 169 .
Pang C , Zhang XL , Zhang XL , et al . Effect of fresh Dendrobium officinalis on the expression of autophagy and tumor suppressor gene in lung transplanted tumor tissues in nude mice [J ] . Her Med , 2021 , 40 ( 2 ): 163 - 169 .
林岳岩 , 张秀玲 , 韦 明 , 等 . 鲜铁皮石斛对肺腺癌A549细胞的作用及其可能机制 [J ] . 广西医学 , 2022 , 44 ( 22 ): 2645 - 2648,2683 .
Lin YY , Zhang XL , Wei M , et al . Effect of fresh Dendrobium candidum on pulmonary adenocarcinoma A 549 cells and its possible mechanism [J ] . Guangxi Med J , 2022 , 44 ( 22 ): 2645 - 2648,2683 .
肖 岚 , 彭 壮 , 易 健 , 等 . 玉竹多糖抗肺癌肿瘤活性及其机制研究 [J ] . 时珍国医国药 , 2018 , 29 ( 10 ): 2368 - 2372 .
Xiao L , Peng Z , Yi J , et al . Study on anti-lung tumor activity and mechanisms of Polygonatum polysaccharide [J ] . Lishizhen Med Mater Med Res , 2018 , 29 ( 10 ): 2368 - 2372 .
梁亚男 , 姜婉茹 , 常文惠 , 等 . 玉竹多酚成分及其对二氧化硅诱导的A549细胞损伤的保护作用研究 [J ] . 沈阳药科大学学报 , 2023 , 40 ( 3 ): 300 - 308,349 .
Liang YN , Jiang WR , Chang WH , et al . The polyphenol constituents of Polygonatum odoratum and their cytoprotective activities against SiO 2 -induced A549 cells damage [J ] . J Shenyang Pharm Univ , 2023 , 40 ( 3 ): 300 - 308,349 .
丁淑敏 . 墨旱莲防治肺癌物质基础组分结构研究 [D ] . 南京 : 南京中医药大学 , 2014 .
Ding SM . Study on material basis of Eclipta prostrata L . in the prevention and treatment of lung cancer based on component structure theory[D ] . Nanjing : Nanjing University of Chinese Medicine , 2014 .
Han J , Lv W , Sheng HX , et al . Ecliptasaponin A induces apoptosis through the activation of ASK1/JNK pathway and autophagy in human lung cancer cells [J ] . Ann Transl Med , 2019 , 7 ( 20 ): 539 .
余娅娅 , 朱燕娟 , 肖真真 , 等 . 知母、干姜对PI3K/AKT通路异常激活介导的非小细胞肺癌吉非替尼耐药的影响及机制研究 [J ] . 中药新药与临床药理 , 2023 , 34 ( 11 ): 1525 - 1533 .
Yu YY , Zhu YJ , Xiao ZZ , et al . Effect and mechanism study of anemarrhenae rhizoma and zingiberis rhizoma recens on gefitinib resistance in non-small cell lung cancer mediated by abnormal activation of PI3K/AKT pathway [J ] . Tradit Chin Drug Res Clin Pharmacol , 2023 , 34 ( 11 ): 1525 - 1533 .
张慧琼 , 李刚敏 , 陈俊仁 , 等 . 西洋参总皂苷联合顺铂对Luc-A549肺癌小鼠瘤体生长的影响 [J ] . 中药药理与临床 , 2021 , 37 ( 3 ): 50 - 55 .
Zhang HQ , Li GM , Chen JR , et al . Effect of total saponins in panacis quinquefolii Radix combined with cisplatin on tumor growth in mice bearing luc-A549 cells [J ] . Pharmacol Clin Chin Mater Med , 2021 , 37 ( 3 ): 50 - 55 .
Wang Y , Yang SY , Pan YN , et al . Influences of Shashen Maidong decoction (沙参麦冬汤)-containing serum combined with cisplatin on expressions of E-cadherin and snail inlung adenocarcinoma A549 cells [J ] . Chin Arch Tradit Chin Med , 2021 , 39 ( 8 ): 62 - 65,7 .
王 莹 , 杨斯洋 , 潘一诺 , 等 . 沙参麦冬汤含药血清联合顺铂对A549细胞E-cadherin和Snail的影响 [J ] . 中华中医药学刊 , 2021 , 39 ( 8 ): 62 - 65,7 .
刘亚琪 , 郭明星 , 甘盼盼 , 等 . 基于GLUT1/HK2代谢轴探讨沙参麦冬汤含药血清对人非小细胞肺癌A549细胞增殖、侵袭、迁移和凋亡的影响 [J ] . 中药药理与临床 , 2025 , 41 ( 9 ): 15 - 20 .
Liu YQ , Guo MX , Gan PP , et al . Effects of Shashen(沙参) Maidong(麦冬) decoction-containing serum on proliferation,invasion,migration,and apoptosis of human non-small cell lung cancer A549 cells based on GLUT1/HK2 metabolic axis [J ] . Pharmacol Clin Chin Mater Med , 2025 , 41 ( 9 ): 15 - 20 .
余 霖 , 王瑶瑶 , 刘丽敏 , 等 . 沙参麦冬汤调控JAK2/STAT3信号通路对Lewis肺癌模型小鼠化疗增效机制 [J ] . 中国实验方剂学杂志 , 2026 , 32 ( 5 ): 1 - 10 .
Yu L , Wang YY , Liu LM , et al . Shashen Maidong Tang enhances efficacy of chemotherapy in mouse model of lewis lung cancer by modulating JAK2/STAT3 signaling pathway [J ] . Chin J Exp Tradit Med Formulae , 2026 , 32 ( 5 ): 1 - 10 .
Zhou J , Liu Z G , Tan J L . Mechanism of Baihe Gujin Decoction in the treatment ofnon-small cell lung cancer . J Hunan Normal Univ , 2021 , 18 ( 2 ): 8 - 12 .
Zhao SH , Wang WH , Liang YC , et al . Research progress of Baihe Gujin decoction in the treatment of lung cancer [J ] . Cancer Manag Res , 2024 , 16 : 347 - 359 .
孙莎莎 , 谢美萍 , 孙玉侠 , 等 . 基于ATF2和JAK2/STAT3信号通路研究麦门冬汤合千金苇茎汤联合顺铂对Lewis肺癌小鼠的抑瘤作用 [J ] . 中药材 , 2023 , 46 ( 7 ): 1753 - 1759 .
Sun SS , Xie MP , Sun YX , et al . Effect of Maimendong decoction and Qianjinweijing decoction combined with cisplatin on tumor inhibition of mice with lewis lung cancer based on ATF2 and JAK2/STAT3 signaling pathway [J ] . J Chin Med Mater , 2023 , 46 ( 7 ): 1753 - 1759 .
刘莲芳 , 卢子涵 , 胡 霞 , 等 . 益气养阴解毒方对Lewis肺癌小鼠的免疫调节及抗肿瘤作用 [J ] . 南京中医药大学学报 , 2025 , 41 ( 1 ): 95 - 101 .
Liu LF , Lu ZH , Hu X , et al . Immunoregulation and antitumor effect of Yiqi Yangyin Jiedu recipe on lewis lung cancer mice [J ] . J Nanjing Univ Tradit Chin Med , 2025 , 41 ( 1 ): 95 - 101 .
姜 怡 , 蔡雨晴 , 张 朋 , 等 . 益气养阴解毒方及黄芪甲苷体外对CTLA⁃4介导的肺癌免疫逃逸的影响 [J ] . 中成药 , 2021 ( 8 ): 2173 - 2177 .
Jiang Y , Cai YQ , Zhang P , et al . Effects of Yiqi Yangyin Jiedu recipe and Astragaloside IV on immune escape of lung cancer mediated by CTLA⁃4 in vitro [J ] . Chin Tradit Pat Med , 2021 ( 8 ): 2173 - 2177 .
胡 霞 , 潘迎英 , 周勤峰 , 等 . 益气养阴解毒方联合化疗治疗晚期非小细胞肺癌临床疗效观察 [J ] . 贵州中医药大学学报 , 2022 , 44 ( 4 ): 32 - 37 .
Hu X , Pan YY , Zhou QF , et al . Clinical observation of Yiqi Yangyin Jiedu recipe combined with chemotherapy in the treatment of advanced non-small cell lung cancer [J ] . J Guizhou Univ Tradit Chin Med , 2022 , 44 ( 4 ): 32 - 37 .
焦安男 , 吴 欢 , 朱 洁 , 等 . 芪玉三龙汤通过PD-1信号通路增强Th1免疫反应抑制肺癌转移 [J ] . 安徽医科大学学报 , 2022 , 57 ( 11 ): 1718 - 1724 .
Jiao AN , Wu H , Zhu J , et al . Qiyu Sanlong Decoction enhances Th1 immune response through PD-1 signaling pathway and inhibits metastasis of lung cancer [J ] . Acta Univ Med Anhui , 2022 , 57 ( 11 ): 1718 - 1724 .
高雅婷 , 王心恒 , 王小乐 , 等 . 芪玉三龙汤调节mTOR/Beclin1/LC3信号轴相关分子的表达诱导肺癌A549细胞自噬 [J ] . 中国实验方剂学杂志 , 2021 , 27 ( 1 ): 98 - 104 .
Gao YT , Wang XH , Wang XL , et al . Effect of qiyu sanlong decoction in inducing autophagy of A549 cells by regulating molecular expression related to signal axis of mTOR-Beclin1-LC3 [J ] . Chin J Exp Tradit Med Formulae , 2021 , 27 ( 1 ): 98 - 104 .
徐维升 , 焦安男 , 顾经华 , 等 . 芪玉三龙汤通过PTEN通路诱导M2/M1巨噬细胞极化改善小鼠非小细胞肺癌肿瘤免疫微环境的机制研究 [J ] . 药物评价研究 , 2025 , 48 ( 4 ): 820 - 832 .
Xu WS , Jiao AN , Gu JH , et al . Mechanism of Qiyu Sanlong Decoction inducing M2/M1 macrophage polarization to improve the immune microenvironment of non-small cell lung cancer in mice through PTEN pathway [J ] . Drug Eval Res , 2025 , 48 ( 4 ): 820 - 832 .
Xie YG , Lu YL , Hu B , et al . Action mechanism of Shiquan Yuzhen Tang(十全育真汤)in the treatment of non-small cell lung cancer based on network pharmacology [J ] . J Gansu Univ Chin Med , 2021 , 38 ( 5 ): 37 - 43 .
谢雅革 , 卢艳琳 , 胡 兵 , 等 . 基于网络药理学研究十全育真汤治疗非小细胞肺癌的作用机制 [J ] . 甘肃中医药大学学报 , 2021 , 38 ( 5 ): 37 - 43 .
谢雅革 . 十全育真汤治疗非小细胞肺癌作用及机制研究 [D ] . 上海 : 上海中医药大学 , 2020 .
Xie YG . The effects and mechanism of Shiquan yuzhen decoction on non-small cell lung cancer [D ] . Shanghai : Shanghai University of Traditional Chinese Medicine , 2020 .
吴凤美 , 于忠和 , 张秀良 , 等 . 十全育真汤对肺腺癌化疗患者免疫功能及凝血功能的影响 [J ] . 内蒙古中医药 , 2023 , 42 ( 6 ): 22 - 23 .
Wu FM , Yu ZH , Zhang XL , et al . Effect of Shiquan Yuzhen decoction on immune function and coagulation function of lung adenocarcinoma patients undergoing chemotherapy [J ] . Inn Mong J Tradit Chin Med , 2023 , 42 ( 6 ): 22 - 23 .
柏正平 , 刘 雨 , 谭小宁 , 等 . 金水六君煎及其拆方含药血清对A549细胞中黏蛋白MUC5AC及水通道蛋白AQP5表达的影响 [J ] . 湖南中医药大学学报 , 2019 , 39 ( 3 ): 320 - 325 .
Bai ZP , Liu Y , Tan XN , et al . Effects of serum containing Jinshui Liujun decoction and its components on the expression of mucin MUC5AC and aquaporin AQP5 in A549 cell mucus hypersecretion model [J ] . J Tradit Chin Med Univ Hunan , 2019 , 39 ( 3 ): 320 - 325 .
徐文聃 , 戴世杰 , 李哲明 , 等 . 六味地黄丸对肾阴虚大鼠肺肾组织水通道蛋白1表达的影响 [J ] . 中华中医药杂志 , 2015 , 30 ( 4 ): 1242 - 1245 .
Xu WD , Dai SJ , Li ZM , et al . Effects of Liuwei Dihuang Wan on AQP1 expression of lung and kidney in kidney-Yin deficiency model rats [J ] . China J Tradit Chin Med Pharm , 2015 , 30 ( 4 ): 1242 - 1245 .
张天宇 . 养阴清肺汤加味调节SMPP小鼠气血屏障的机制研究 [D ] . 沈阳 : 辽宁中医药大学 , 2022 .
Zhang TY . Mechanism of Modified Yangyin Qingfei Tang in regulating the blood-Air barrier in mice with Severe Mycoplasma Pneumoniae (SMPP) [D ] . Shenyang : Liaoning University of Traditional Chinese Medicine , 2022 .
王志旺 , 刘雪枫 , 程小丽 , 等 . 当归对阴虚哮喘小鼠的平喘作用及肺组织中水通道蛋白5表达的影响 [J ] . 华西药学杂志 , 2016 , 31 ( 3 ): 235 - 238 .
Wang ZW , Liu XF , Cheng XL , et al . Effects of Angelicae sinensis Radix on anti-asthma and the expression of aquaporin-5 in the lung tissue of asthmatic mice with Yin deficiency syndrome [J ] . West China J Pharm Sci , 2016 , 31 ( 3 ): 235 - 238 .
Xiong MY , Li CL , Wang WD , et al . Protein structure and modification of aquaporins [M ] // Aquaporins . Singapore : Springer Nature Singapore , 2023 : 15 - 38 .
Bhattacharjee A , Jana A , Bhattacharjee S , et al . The role of Aquaporins in tumorigenesis: implications for therapeutic development [J ] . Cell Commun Signal , 2024 , 22 ( 1 ): 106 .
Wagner K , Unger L , Salman MM , et al . Signaling mechanisms and pharmacological modulators governing diverse aquaporin functions in human health and disease [J ] . Int J Mol Sci , 2022 , 23 ( 3 ): 1388 .
Moon CS , Moon D , Kang SK . Aquaporins in cancer biology [J ] . Front Oncol , 2022 , 12 : 782829 .
李秋静 , 姜青梅 , 张 梅 , 等 . 肺腺癌组织中水通道蛋白1高表达对患者康复和预后指导 [J ] . 中国急救复苏与灾害医学杂志 , 2022 , 17 ( 6 ): 763 - 766 .
Li QJ , Jiang QM , Zhang M , et al . High expression of aquaporin 1 in lung adenocarcinoma tissue as a guide to patient recovery and prognosis [J ] . China J Emerg Resusc Disaster Med , 2022 , 17 ( 6 ): 763 - 766 .
马亚文 , Bingling Xu , 刘丽华 . 水通道蛋白1与非小细胞肺癌的相关性研究 [J ] . 医学信息 , 2022 ( 6 ): 73 - 76 .
Ma YW , Bingling X , Liu LH . Study on the correlation between AQP1 and non-small cell lung cancer [J ] . J Med Inf , 2022 ( 6 ): 73 - 76 .
王会峰 , 董 辉 , 吴媛媛 , 等 . 过表达水通道蛋白1(AQP1)促进A549人肺腺癌细胞的增殖并抑制β联蛋白(β-catenin)磷酸化 [J ] . 细胞与分子免疫学杂志 , 2020 , 36 ( 5 ): 413 - 418 .
Wang HF , Dong H , Wu YY , et al . Over-expression of aquaporin 1 (AQP1) promotes cell proliferation and inhibits β-catenin phosphorylation in human lung adenocarcinoma A549 cells [J ] . Chin J Cell Mol Immunol , 2020 , 36 ( 5 ): 413 - 418 .
Ji YN , Liao XM , Jiang Y , et al . Aquaporin 1 knockdown inhibits triple-negative breast cancer cell proliferation and invasion in vitro and in vivo [J ] . Oncol Lett , 2021 , 21 ( 6 ): 437 .
危 敏 , 余海浪 , 孙 鹏 , 等 . AQP1通过Wnt通路促进乳腺癌MCF-7细胞增殖、迁移与侵袭 [J ] . 现代肿瘤医学 , 2022 , 30 ( 7 ): 1152 - 1159 .
Wei M , Yu HL , Sun P , et al . AQP1 promotes proliferation,migration and invasion of breast cancer MCF-7 cells through Wnt pathway [J ] . J Mod Oncol , 2022 , 30 ( 7 ): 1152 - 1159 .
王雅玮 . AQP3介导活性氧跨膜转运调控肺腺癌细胞自噬的分子机制研究 [D ] . 沈阳 : 中国医科大学 , 2022 .
Wang YW . The mechanism study of AQP3-mediated ROS transmembrane transportation regulating lung adenocarcinoma autophagy [D ] . Shenyang : China Medical University , 2022 . [73 ] LiuC,LiuL,ZhangY,et al. Molecular mechanism of AQP3 in regulating differentiation and apoptosis of lung cancer stem cells through Wnt/GSK-3β/β-Catenin pathway. J BUON , 2020 , 25 ( 4 ): 1714 - 1720 .
Wu XH , Wu GZ , Zhang HZ , et al . MiR-196b promotes the invasion and migration of lung adenocarcinoma cells by targeting AQP4 [J ] . Technol Cancer Res Treat , 2021 , 20 : 1533033820985868 .
张 琦 , 周永春 , 洪文娟 , 等 . 水通道蛋白AQP4对肺癌细胞增殖的影响 [J ] . 基因组学与应用生物学 , 2016 , 35 ( 11 ): 2885 - 2889 .
Zhang Q , Zhou YC , Hong WJ , et al . Effect of aquaporin-4(AQP4) on proliferation of lung cancer cells [J ] . Genom Appl Biol , 2016 , 35 ( 11 ): 2885 - 2889 .
周永春 , 张 琦 , 陈琬玲 , 等 . 水通道蛋白4对肺癌细胞A549迁移能力的影响及其作用机制研究 [J ] . 实用心脑肺血管病杂志 , 2016 , 24 ( 12 ): 55 - 58 .
Zhou YC , Zhang Q , Chen WL , et al . Impact of aquaporin 4 on migration of lung cancer A549 cells and the mechanism [J ] . Pract J Card Cereb Pneumal Vasc Dis , 2016 , 24 ( 12 ): 55 - 58 .
李英彬 , 孙圣荣 . 水通道蛋白4在乳腺癌细胞侵袭转移中的作用 [J ] . 临床外科杂志 , 2020 , 28 ( 1 ): 54 - 57 .
Li YB , Sun SR . Effect of aquaporin AQP4 in invasion and metastasis of breast cancer cells [J ] . J Clin Surg , 2020 , 28 ( 1 ): 54 - 57 .
李英彬 , 孙圣荣 . 水通道蛋白AQP4对乳腺癌细胞增殖的影响及机制 [J ] . 现代肿瘤医学 , 2019 , 27 ( 6 ): 943 - 946 .
Li YB , Sun SR . Effect and mechanism of aquaporin AQP4 on proliferation of breast cancer cells [J ] . J Mod Oncol , 2019 , 27 ( 6 ): 943 - 946 .
盛 旺 , 吕晓君 , 安汉祥 . 肺癌组织中水通道蛋白的表达及其与上皮-间质转化的相关性 [J ] . 中国老年学杂志 , 2015 , 35 ( 2 ): 362 - 363 .
Sheng W , Lv XJ , An HX . Expression of aquaporin in lung cancer and its correlation with epithelial-mesenchymal transition [J ] . Chin J Gerontol , 2015 , 35 ( 2 ): 362 - 363 .
Elkhider A , Wang B , Ouyang X , et al . Aquaporin 5 promotes tumor migration and angiogenesis in non-small cell lung cancer cell line H1299 [J ] . Oncol Lett , 2020 : 19 ( 3 ): 1665 - 1672 .
Jaskiewicz L , Romaszko-Wojtowicz A , Doboszynska A , et al . The role of aquaporin 5 (AQP5) in lung adenocarcinoma: a review article [J ] . Cells , 2023 , 12 ( 3 ): 468 .
Parveen S , Fatma M , Mir S , et al . JAK-STAT signaling in autoimmunity and cancer [J ] . ImmunoTargets Ther , 2025 , 14 : 523 - 554 .
0
Views
0
下载量
0
CSCD
Publicity Resources
Related Articles
Related Author
Related Institution
京公网安备11010802024621
