成都中医药大学针灸推拿学院,成都 610075
Received:08 January 2026,
Revised:2026-03-04,
Accepted:12 March 2026,
Online First:10 June 2026,
移动端阅览
He ,Cheng Kexin,Li Yanqiu,et al.Yue Research advances in the mechanism of acupuncture in regulating mitochondrial injury[J].Journal of Chongqing Medical University,
He ,Cheng Kexin,Li Yanqiu,et al.Yue Research advances in the mechanism of acupuncture in regulating mitochondrial injury[J].Journal of Chongqing Medical University, DOI:10.13406/j.cnki.cyxb..
线粒体作为细胞能量代谢的核心细胞器,其功能损伤与多种疾病的发生发展密切相关。近年来研究发现,针刺作为一种整体性调节疗法,可能通过多靶点、多层次调控线粒体功能。随着中医现代化研究的深入,传统针刺疗法与线粒体生物学之间的关联日益受到关注,本文从线粒体氧化应激、动力学、自噬、细胞凋亡、生物发生等多个维度,系统综述近年来针刺调控线粒体功能的研究进展,并深入探讨在不同疾病模型条件下其分子机制,以期为基于线粒体靶点的针刺研究提供参考。
Mitochondria are central organelles in cellular energy metabolism,and the functional impairment of mitochondria is closely associated with the development and progression of various diseases. Recent studies have shown that as a holistic regulatory therapy,acupuncture may modulate mitochondrial function through multiple targets and pathways. With the in-depth research on modern traditional Chinese medicine,the connection between traditional acupuncture therapy and mitochondrial biology has attracted increasing attention. This article systematically reviews the recent research advances in the role of acupuncture in regulating mitochondrial function from multiple dimensions,including mitochondrial oxidative stress,mitochondrial dynamics,mitophagy,apoptosis,and mitochondrial biogenesis,as well as related molecular mechanisms in various disease models,in order to provide a reference for the research on acupuncture targeting mitochondrial pathways.
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