Therapeutic effect of repetitive upright training in treatment of patients with Parkinson’s disease and orthostatic hypotension: a case report

Ding Zeyu; Feng Xueyan; Jiang Qianmei; Tian Ruopu; Ji Zeqiang; Liu Jiexin

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Therapeutic effect of repetitive upright training in treatment of patients with Parkinson’s disease and orthostatic hypotension: a case report

更新时间：2026-06-10

- Therapeutic effect of repetitive upright training in treatment of patients with Parkinson’s disease and orthostatic hypotension: a case report
- Journal of Chongqing Medical University Pages: 1-5(2026)
- 作者机构：
  
  首都医科大学附属北京天坛医院神经病学中心，北京 100070
- 作者简介：
- 基金信息：
- DOI：
  CLC： R544.2
- Received：07 January 2026，
  
  Revised：2026-03-26，
  
  Accepted：28 April 2026，
  
  Online First：10 June 2026，
- 稿件说明：
移动端阅览
Ding Zeyu,Feng Xueyan,Jiang Qianmei,et al.Therapeutic effect of repetitive upright training in treatment of patients with Parkinson’s disease and orthostatic hypotension: a case report[J].Journal of Chongqing Medical University,
DOI：

Ding Zeyu,Feng Xueyan,Jiang Qianmei,et al.Therapeutic effect of repetitive upright training in treatment of patients with Parkinson’s disease and orthostatic hypotension: a case report[J].Journal of Chongqing Medical University, DOI：10.13406/j.cnki.cyxb..

摘要

目的

探讨反复直立训练对1例帕金森患者合并严重直立性低血压（orthostatic hypotension，OH）的疗效。

方法

训练前行直立倾斜试验（head-up tilt test，HUTT），给予每日1次反复直立训练8次后，复查HUTT。继续给予1次/d反复直立训练8次后复查HUTT。比较3次HUTT结果，判断疗效。

结果

第1次HUTT复查结果显示直立耐受时间由2.5 min延长至15 min。第2次HUTT结果显示直立耐受时间延长至35 min。最后，患者的OH严重程度分级由3级变为2级。

结论

反复直立训练对严重OH有快速和显著的治疗效果。

Abstract

Objective

To investigate the therapeutic effect of repetitive upright training in the treatment of a patient with Parkinson’s disease and severe orthostatic hypotension（OH）.

Methods

The head-up tilt test（HUTT） was performed before training and after 8 sessions of daily repetitive upright training. Another 8 sessions of daily repetitive upright training were performed，and then HUTT was performed again. The results of the three HUTT assessments were compared to evaluate therapeutic effect.

Results

The first HUTT reexamination showed that the upright tolerance time was prolonged from 2.5 minutes to 15 minutes. The second HUTT reexamination showed that the upright tolerance time was prolonged to 35 minutes. Finally，the severity of OH in this patient was reduced from grade 3 to grade 2.

Conclusion

Repetitive upright training has a rapid and significant therapeutic effect on severe OH.

关键词

Keywords

references

Logan A ， Freeman J ， Pooler J ， et al . Effectiveness of non-pharmacological interventions to treat orthostatic hypotension in elderly people and people with a neurological condition：a systematic review [J ] . JBI Evid Synth ， 2020 ， 18 （ 12 ）： 2556 - 2617 .

Subbarayan S ， Myint PK ， Martin KR ， et al . Nonpharmacologic management of orthostatic hypotension in older people： a systematic review. the SENATOR ONTOP series [J ] . J Am Med Dir Assoc ， 2019 ， 20 （ 9 ）： 1065 - 1073 . e3.

Brignole M ， Moya A ， De Lange FJ ， et al . 2018 ESC Guidelines for the diagnosis and management of Syncope [J ] . Kardiol Pol ， 2018 ， 76 （ 8 ）： 1119 - 1198 .

Berger MJ ， Kimpinski K . A practical guide to the treatment of neurogenic orthostatic hypotension [J ] . Can J Neurol Sci ， 2014 ， 41 （ 2 ）： 156 - 163 .

刘　敏，宫献文，吴　萍，等 . SUP/HUT反复体位改变对心血管反应和脑血氧的影响研究 [J ] . 载人航天， 2016 ， 22 （ 6 ）： 720 - 726 .

Liu M ， Gong XW ， Wu P ， et al . Influences of SUP/HUT repeated body position change test on cardiovascular response and cerebral oxygenation [J ] . Manned Spacefl ， 2016 ， 22 （ 6 ）： 720 - 726 .

刘杰昕，杜　嵩，王　跃，等 . 0.25?mg低剂量硝酸甘油激发直立倾斜试验在血管迷走性晕厥诊断中的应用 [J ] . 中国卒中杂志， 2020 ， 15 （ 6 ）： 637 - 643 .

Liu JX ， Du S ， Wang Y ， et al . Application value of 0.25 Mg low-dose nitroglycerin-stimulated head-up tilt test for the diagnosis of vasovagal Syncope [J ] . Chin J Stroke ， 2020 ， 15 （ 6 ）： 637 - 643 .

王　含，李　凡，陈琦玲，等 . 直立性低血压诊断与处理中国多学科专家共识 [J ] . 中国循环杂志， 2024 ， 39 （ 11 ）： 1058 - 1069 .

Wang H ， Li F ， Chen QL ， et al . Chinese multidisciplinary expert consensus on diagnosis and management of orthostatic hypotension [J ] . Chin Circ J ， 2024 ， 39 （ 11 ）： 1058 - 1069 .

Hornikx M ， Haemers P ， Stans L ， et al . Tilt training as a treatment for reflex Syncope ： a multimodal approach!? [J ] . Front Neurosci ， 2024 ， 18 ： 1473687 .

Verheyden B ， Ector H ， Aubert AE ， et al . Tilt training increases the vasoconstrictor reserve in patients with neurally mediated Syncope evoked by head-up tilt testing [J ] . Eur Heart J ， 2008 ， 29 （ 12 ）： 1523 - 1530 .

刘杰昕 . 神经心脏病学临床实践 [M ] . 北京：人民卫生出版社， 2024 .

Liu JX . Clinical practice of neurocardiology [M ] . Beijing ： People’s Medical Publishing House ， 2024 .

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