山东中医药大学医学院,济南 250355
Received:08 February 2026,
Revised:2026-04-28,
Accepted:30 April 2026,
Published:25 May 2026
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Yang Qian,Zhang Yichan,Wang Keya,et al.Research advances in the regulatory role of the AGE-RAGE axis in lipid metabolism disorders and pharmacological interventions[J].Journal of Chongqing Medical University,
Yang Qian,Zhang Yichan,Wang Keya,et al.Research advances in the regulatory role of the AGE-RAGE axis in lipid metabolism disorders and pharmacological interventions[J].Journal of Chongqing Medical University, DOI:10.13406/j.cnki.cyxb..
脂质代谢疾病是当今生活方式改变背景下的常见疾病,具有发病率高、发病年龄年轻化及并发症多的特点。晚期糖基化终末产物-晚期糖基化终末产物受体(advanced glycation end products-receptor of advanced glycation end products,AGE-RAGE)通路参与多种脂质代谢疾病的发生发展,如脂性肾病、动脉粥样硬化(atherosclerosis,AS)、脂肪肝病等,并与肿瘤代谢重编程等方面相关。AGE-RAGE轴可诱导细胞氧化应激、异常增殖及过度自噬,并通过调控脂质含量、代谢酶、糖转运蛋白及中间代谢过程,广泛参与多种疾病的发生发展。笔者围绕脂质代谢、AS、脂肪肝病、肿瘤脂质重编程和糖尿病这五个方面展开讨论,并对多种药物通过AGE-RAGE轴干预疾病的作用机制进行总结,探索AGE-RAGE通路在疾病治疗中的作用,为脂质代谢疾病的药物应用及开发提供理论依据。
Lipid metabolism disorders have become increasingly common due to modern lifestyle changes,characterized by high prevalence,a trend toward younger onset,and frequent complications. The advanced glycation end products-receptor of advanced glycation end products(AGE-RAGE) pathway plays a critical role in the pathogenesis of various lipid metabolism-related diseases,such as lipid nephropathy,atherosclerosis,fatty liver disease,and even tumor metabolic reprogramming. The AGE-RAGE axis induces oxidative stress,aberrant proliferation,and dysregulated autophagy. It also modulates lipid content,metabolic enzymes,glucose transporters,and key metabolic steps,thereby playing a broad role in the pathogenesis of various diseases. This review focuses on five key aspects:lipid metabolism,atherosclerosis,fatty liver disease,tumor lipid reprogramming,and diabetes. Additionally,it summarizes the mechanisms by which various drugs modulate disease progression through the AGE-RAGE axis,exploring the therapeutic potential of the AGE-RAGE axis and providing a theoretical foundation for drug development and clinical applications in lipid metabolism disorders.
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