1.西安医学院公共卫生学院,西安 710021
2.西安医学院基础医学部,西安 710021
3.西安医学院基础与转化医学研究所,西安 710021
Received:11 November 2025,
Revised:2026-03-18,
Accepted:26 March 2026,
Published:30 March 2026
移动端阅览
Zhao Ruizi,Fu Xinle,Luan Jing,et al.Research advances in the role of intestinal flora in the treatment of chronic gastritis[J].Journal of Chongqing Medical University,
Zhao Ruizi,Fu Xinle,Luan Jing,et al.Research advances in the role of intestinal flora in the treatment of chronic gastritis[J].Journal of Chongqing Medical University, DOI:10.13406/j.cnki.cyxb..
慢性胃炎(chronic gastritis,CG)是一种常见的消化系统疾病,发病率居胃病之首,其发病机制复杂,涉及幽门螺杆菌(helicobacter pylori,Hp)感染、免疫反应异常、十二指肠反流等多种因素,且目前尚无特效治疗手段。最新研究显示,改善肠道微生态对慢性胃炎具有良好的治疗作用。随着对肠道菌群认识的不断深入,其在人类疾病发生、发展中的作用日益受到关注。该综述系统阐述了肠道菌群在慢性胃炎治疗中的作用,内容主要涵盖肠道菌群的组成,肠道菌群的作用,深入分析肠道菌群与慢性胃炎的相关性,通过动物实验与临床研究证据,揭示菌群失衡与胃黏膜损伤、炎症进展的关联;探讨肠道菌群影响慢性胃炎的潜在机制,包括免疫调节、代谢产物调控及胃黏膜屏障保护等关键通路,明确有益菌与有害菌在疾病进程中的不同作用;总结基于肠道菌群的慢性胃炎治疗策略。该综述旨在为慢性胃炎治疗提供新视角和新思路。
Chronic gastritis(CG) is a common disease of the digestive system,ranking first among gastric diseases in terms of incidence rate,and it has a complex pathogenesis involving multiple factors such as
Helicobacter pylori
infection,abnormal immune response,and duod
enal reflux. There is currently no effective therapeutic method for this disease. The latest studies have shown that improving intestinal microecology exerts a favorable therapeutic effect on CG,and with a deeper understanding of intestinal flora,its role in the development and progression of human diseases has attracted wide attention. This article systematically elaborates on the role of intestinal flora in the treatment of CG,covering the composition and function of intestinal flora. It conducts an in-depth analysis of the association between intestinal flora and CG and reveals the association of intestinal flora dysbiosis with gastric mucosal injury and inflammatory progression based on the evidence from animal experiments and clinical studies. Furthermore,this article explores the potential mechanism by which intestinal flora affects CG,including the key pathways such as immune regulation,metabolite modulation,and protection of gastric mucosal barrier,as well as the different roles of probiotic bacteria and pathogenic bacteria during the course of the disease. Finally,it summarizes the treatment strategies for CG based on intestinal flora. This review aims to provide new perspectives and insights for the treatment of CG.
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