Objective To explore the effect of psychological nursing intervention on surgical stress response and postoperative recovery in patients undergoing laparoscopic radical prostate cancer surgery. Methods Ninety-eight patients who underwent laparoscopic radical prostate cancer surgery in a hospital in Mudanjiang from December 2018 to December 2019 were selected for the study. A random number table was used to divide the patients into an observation group and a control group

with 49 cases in each group. The patients in the control group were given conventional nursing interventions

while the patients in the observation group were given psychological nursing interventions in addition to conventional nursing. The visual analog scale（VAS）

Hamilton Anxiety Rating Scale（HAMA） and Hamilton Depression Rating Scale（HAMD） scores of the patients in the two groups were compared before care and at the time of discharge. The levels of cortisol（COR）

adrenaline（AD）

norepinephrine（NE） and C-reactive protein（CRP） before and at 24 h of care were compared between the 2 groups. Results At discharge

the VAS

HAMA and HAMD scores of patients in the observation group were（2.13±0.20）

（9.32±0.91） and（8.99±1.05）

respectively

which were lower than the control group’s（3.85±0.38）

（14.04±1.48） and（13.26±1.37）

with statistically significant differences（P<0.05）. The levels of COR

AD

NE and CRP in the observation group at 24 h of care were（120.41±15.67）ng/L

（131.40±16.96）ng/L

（384.02±49.70）ng/L and（0.49±0.06）mg/d L

respectively

which were lower than the control group’s（134.83±16.82）ng/L

（156.83±20.07）ng/L

（548.34±70.05）ng/L and（0.83±0.10）mg/d L

with statistically significant differences（P<0.05）. The time to first postoperative ventilation

time to recovery of bowel function

time to first defecation

time of catheter retention

time of drainage tube retention and hospital stay in the observation group were（33.25±4.25）h

（22.06±2.82）h

（55.51±7.10）h

（5.59±0.71）d

（6.40±0.82）d and（8.43±1.08）d

all shorter than the（47.58±6.09）h

（29.69±3.80）h

（72.39±9.26）h

（7.42±0.95）d

（8.37±1.06）d and（12.51±1.60）d in the control group

with statistically significant differences（P<0.05）. Conclusion Psychological nursing interventions can reduce the surgical stress response of patients undergoing laparoscopic radical prostate cancer surgery

relieve their pain

relieve adverse emotions such as anxiety and depression

promote the patients’ postoperative recovery

and improve nursing satisfaction

and therefore

it is worthy of wide application and promotion.