Effect of valproic acid i n combination with lamotrigine in the treatment of adult epilepsy and its effect on lamotrigine blood levels

Tong Jiaxu; Jiang Xueming; Liu Yingying

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Effect of valproic acid i n combination with lamotrigine in the treatment of adult epilepsy and its effect on lamotrigine blood levels

更新时间：2021-08-23

- Effect of valproic acid i n combination with lamotrigine in the treatment of adult epilepsy and its effect on lamotrigine blood levels
- Health Medicine Research and Practice Vol. 17, Issue 6, Pages: 37-40(2020)
- 作者机构：
  
  辽阳市第三人民医院神经内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R742.1;R969.1
- Published：2020，
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[1]佟家旭,姜学明,刘莹莹.丙戊酸联合拉莫三嗪治疗成人癫痫的效果及对拉莫三嗪血药浓度的影响[J].保健医学研究与实践,2020,17(06):37-40.

Tong Jiaxu, Jiang Xueming, Liu Yingying. Effect of valproic acid i n combination with lamotrigine in the treatment of adult epilepsy and its effect on lamotrigine blood levels. [J]. Health Medicine Research and Practice 17(6):37-40(2020)
[1]佟家旭,姜学明,刘莹莹.丙戊酸联合拉莫三嗪治疗成人癫痫的效果及对拉莫三嗪血药浓度的影响[J].保健医学研究与实践,2020,17(06):37-40. DOI：

Tong Jiaxu, Jiang Xueming, Liu Yingying. Effect of valproic acid i n combination with lamotrigine in the treatment of adult epilepsy and its effect on lamotrigine blood levels. [J]. Health Medicine Research and Practice 17(6):37-40(2020) DOI：

摘要

目的探讨丙戊酸联合拉莫三嗪对成人癫痫的治疗效果以及丙戊酸对拉莫三嗪血药浓度的影响。方法选取辽宁省某医院2018年1月—2019年5月诊治的120例成年癫痫患者为研究对象

采用随机数字表法分为观察组和对照组

每组60例。对照组患者给予拉莫三嗪治疗

观察组患者在对照组基础上联用丙戊酸进行治疗

均治疗3个月。比较2组患者临床疗效以及治疗前后的血清指标水平

治疗后拉莫三嗪血药浓度、日剂量及不良反应。结果观察组患者的治疗总有效率为91.67%（55/60）

高于对照组的78.33%（47/60）

差异有统计学意义（P<0.05）。治疗后

观察组患者的拉莫三嗪血药浓度、日剂量均明显高于对照组

差异有统计学意义（P<0.05）。治疗前

2组患者血清肿瘤坏死因子-α（TNF-α）、同型半胱氨酸（Hcy）及神经元特异性烯醇化酶（NSE）水平比较

差异无统计学意义（P>0.05）;治疗后

2组患者血清TNF-α、Hcy及NSE水平均低于治疗前

且观察组患者低于对照组

差异均有统计学意义（P<0.05）。2组患者治疗期间不良反应发生率比较

差异无统计学意义（P>0.05）。结论丙戊酸联合拉莫三嗪治疗成人癫痫的疗效较好

丙戊酸可明显提高拉莫三嗪血药浓度

因此联合用药时需根据患者的血药浓度调整拉莫三嗪剂量

以保证用药安全。

Abstract

Objective To investigate the therapeutic effect of valproic acid combined with lamotrigine on adult epilepsy and its effect on the patiens’ lamotrigine blood concentration. Methods One hundred and twenty adult epilepsy patients diagnosed and treated from January 2018 to May 2019 in a hospital in Liaoning were selected and divided into an observation group and a control group with 60 patients in each group using a random number table. Patients in the control group were treated with lamotrigine

and patients in the observation group were treated with valproic acid in combination with lamotrigine

both for 3 months. The clinical efficacy

serum index levels before and after treatment

lamotrigine blood concentration

daily dose and adverse effects were compared between the two groups. Results The total efficacy of treatment in the observation group was 91.67%（55/60）

which was higher than the 78.33%（47/60） in the control group

and the difference was statistically significant（P<0.05）. After treatment

the blood concentration of lamotrigine in the observation group and the average daily dose were significantly higher than the baseline

and the difference was statistically significant（P<0.05）.Before treatment

the serum levels of tumor necrosis factor-α（TNF-α）

homocysteine（Hcy） and neuron-specific enolase（NSE） in the 2 groups were compared

and the differences were not statistically significant（P>0.05）; after treatment

the serum levels of TNF-α

Hcy and NSE in the 2 groups were lower than those before treatment

and those in the observation group were significantly lower than those in the control group（P<0.05）.The incidence of adverse reactions during treatment in the 2 groups was compared

and the difference was not statistically significant（P>0.05）. Conclusion Valproic acid combined with lamotrigine is effective in the treatment of adult epilepsy and can significantly increase the blood concentration of lamotrigine; therefore

the dose of lamotrigine should be adjusted according to the blood concentration of the patients to ensure the safety when using the drug.

关键词

拉莫三嗪丙戊酸成人癫痫血药浓度炎症因子

Keywords

LamotrigineValproic acidAdult epilepsyBlood levelsInflammatory factors

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