Objective To explore the application of continuous renal replacement therapy in burn wound sepsis. Methods Sixty patients with burn wound sepsis admitted to a hospital in Xinxiang City from June 2015 to September 2019 were selected

and the patients were divided into an observation group（22 cases） and a control group（38 cases） according to the treatment plan. Patients in the control group were given conventional treatment

and patients in the observation group were given continuous renal replacement therapy on the basis of the treatment in the control group. The vital parameters（mean arterial pressure

heart rate

blood oxygen saturation）

serum biochemical parameters（blood urea nitrogen

blood creatinine

blood sodium

blood potassium） before treatment and at 2 weeks of treatment as well as the mortality rate were compared between the two groups after 2 months of treatment. Results Before the treatment

the differences between the 2 groups of patients in terms of vital parameters（mean arterial pressure

heart rate and blood oxygen saturation） were not statistically significant（P>0.05）. At 2 weeks of treatment

the mean arterial pressure and oxygen saturation of the patients in the observation group were higher than those before treatment

and at the same time

significantly higher than the control group（P<0.05）. At 2 weeks of treatment

the heart rate of patients in the observation group was lower than that before treatment

and at the same time

significantly lower than the control group（P<0.05）. Before treatment

the differences in serum biochemical indexes（blood urea nitrogen

blood creatinine

blood potassium and blood sodium） between the 2 groups of patients were not statistically significant（P>0.05）. At 2 weeks of treatment

the blood urea nitrogen

creatinine

potassium and sodium in the observation group were all lower than those before treatment

and at the same time

significantly lower than the control group（P<0.05）.The number of deaths in the observation group was 7

and the mortality rate was 31.8%. The number of deaths in the control group was 25 cases

and the mortality rate was 65.8%. The difference was statistically significant（P<0.05）. Conclusion Continuous renal replacement therapy can improve all vital signs and serum biochemical parameters of patients with burn wound sepsis and significantly reduce the risk of death of patients

and therefore

is worthy of clinical promotion and use.