Objective To investigate the effects of tiotropium bromide combined with non-invasive ventilator therapy on blood gas index

respiratory function and inflammatory factor levels in patients with pneumoconiosis complicated with respiratory failure. Methods A total of 110 patients with pneumoconiosis and respiratory failure who were admitted to a hospital in Anhui Province from April 2018 to November 2019 were selected as the research subjects. The patients were divided into a control group（55 cases） and a study group（55 cases） using a random number table method. Patients in the control group were treated with tiotropium bromide

patients in the study group were treated with tiotropium bromide combined with non-invasive ventilator

and the patients in both groups were continuously treated for 14 days. Compare the clinical effects of the two groups of patients; compare the heart rate

respiratory rate

and blood gas indexes of the two groups of patients before and after treatment [arterial blood oxygen pressure（PaO

2

）

arterial carbon dioxide pressure（PaCO

2

）

blood oxygen saturation（Sa O

2

）

and plasma p H value]

Respiratory mechanics indicators [peak air pressure(P

peak

)

static compliance（Cst） and airway resistance（RAW）]

inflammatory factor indicators [C reactive protein（CRP）

tumor necrosis factor-α（TNF-α）

Interleukin-27（IL-27） and procalcitonin（PCT）]

. Results Before treatment

there was no significant difference in heart rate

respiratory rate

Pa O

2

Pa CO

2

Sa O

2

and plasma p H between the two groups（P

>

0.05）. After treatment

the heart rate

respiratory rate

and Pa CO

2

of the two groups were significantly lower than before treatment

and the patients in the study group were lower than the control group

and the differences were statistically significant（P

<

0.05）; Pa O

2

and Sa O

2

were significantly higher in the two groups. Before treatment

and the patients in the study group were higher than the control group

the differences were statistically significant（P

<

0.05）; the plasma p H values of the two groups were higher than before treatment

and the difference was not statistically significant（P

>

0.05）. The patients were higher than the control group

and the difference was statistically significant（P

<

0.05）. Before treatment

there was no significant difference in P

peak

Cst and RAW between the two groups（P

>

0.05）. After treatment

the P

peak

and RAW of the two groups were significantly lower than before the treatment

and the patients in the study group were lower than the control group

the differences were statistically significant（P

<

0.05）; the Cst of the two groups was significantly higher than before the treatment

and the study group The patients were higher than the control group

and the difference was statistically significant（P

<

0.05）. Before treatment

there was no significant difference in the levels of CRP

TNF-α

IL-27 and PCT between the two groups of patients（P

<

0.05）. After treatment

the levels of CRP

TNF-α

IL-27 and PCT in the two groups were significantly lower than before treatment

and the patients in the study group were lower than the control group

and the differences were statistically significant（P

>

0.05）. 5 patients in the control group（2 patients with dry oropharynx

2 patients with dizziness

and 1 with nausea）

the incidence of adverse reactions was 9.09%; 5 patients with adverse reactions in the study group（1 patient with dry oropharynx

2 patients with dizziness

1 case of nausea

1 case of flatulence in the stomach）. The incidence of adverse reactions was 9.09%. The total effective number of patients in the control group was 40 and the total effective rate was 72.73%. In the study the total effective rate was 96.36%

the difference was statistically significant（P

<

0.05）. Conclusion Tiotropium bromide combined with non-invasive ventilator therapy can effectively improve the blood gas index and respiratory function

reduce the inflammatory response in patients with pneumoconiosis complicated with respiratory failure

and has significant curative effect. It is worth popularizing and applying.