Objective To investigate the effects of gonadotropin releasing hormone agonist（GnRH-a） combined with Mirena on ovarian function and uterine volume in patients with adenomyosis.Methods Seventy-four patients with adenomyosis who were treated at a Zunyi hospital between February 2015 and June 2017 were included in this study.Based on the use of a random number table

these patients were divided into the trial group（n = 37） or the control group（n =37）.All patients received subcutaneous injection of GnRH-a on the third day of menstruation;and intrauterine Mirena placement was performed after the 4 thGnRHa injection for patients in the trial group.At 6 months

treatment response was compared between the two groups.Besides

luteinizing hormone（LH）

estradiol（E2）

follicle-stimulating hormone（FSH）

ovarian stromal artery peak systolic velocity（PSV）

and uterine volume at baseline and at 6 months were also compared between the two groups.Results The overall response rate in the trial group was significantly higher than that in the control group（97.30% vs.81.08%

P<0.05）.At baseline

the FSH

LH

E2

PSV

and uterine volume were similar between the two groups（P>0.05）.The FSH level was increased compared with baseline in both groups

greater increase in the trial group（11.25±2.74 vs.7.72±1.11 U/L

P<0.05）;the PSV was lower than that at baseline in both groups

with a significantly greater reduction in the trial group（0.054±0.012 vs.0.075±0.016 m/s

P<0.05）;the uterine volume was smaller than that at baseline in both groups

also with a significantly greater reduction in the trial group（101.23±12.47 vs.214.52±18.41 cm3

P<0.05）.Conclusion GnRH-a combined with Mirena has favorable efficacy in treating adenomyosis

which is effective in regulating ovarian function and reducing uterine volume.This combination therapy deserves widespread clinical application.