With the increasingly aging of population worldwide

the prevalence of chronic kidney disease（CKD） is also increasing

and CKD has become a major threat to public health.Compared with the general elderly population

those diagnosed with CKD are more susceptible to weakness

walking impairment

functional limitations

or even severe disabilities.Therefore

weakness is associated with increased hospitalization rate and mortality risk

as well as poorer quality of life in elderly patients with CKD

which needs attention of both nephrologists and geriatrists.As there is a strong correlation between weakness and poor prognosis in elderly patients with CKD

conventional specialized treatment alone is far from enough.Instead

it is important to transform treatment modalities and management modes

focus on holistic functional rehabilitation

develop patient-centered and individualized weakness management regimen

prevent disease progression

reduce fall

disability and other risks

and maximize patient quality of life.This article reviews the mechanism of weakness and its management in elderly patients with CKD

and identifies several critical aspects of weakness management

including overall evaluation

development of nursing plan

development of nutritional regimen

and development of individualized exercise program.