Objective To investigate the effect of optimized healthy behavior intervention on insulin resistance index（HOMA-IR）and fatty liver index（FLI）in patients with type 2 diabetes and nonalcoholic fatty liver disease（NAFLD）.Methods A total of 98 patients with type 2 diabetes and NAFLD treated at a Luohe hospital between January 2016 and December 2016 were included in this study.Based on a random number table

patients were allocated to receive optimized healthy behavior intervention（trial group

n=49）or conventional healthy behavior intervention（control group

n=49）.The fasting blood glucose（FBG）

alanine aminotransferase（ALT）

aspartate aminotransferase（AST）

total cholesterol（TC）

triglyceride（TG）

and low-density lipoprotein（LDL-C）;as well as HOMA-IR and FLI were determined at baseline and 12 weeks after intervention.The intervention effectiveness was compared between the two groups.Results The overall response rate was significantly higher in the trial group compared with that in the control group（89.8% versus 65.3%

χ2=8.44

P<0.05）.Before intervention

the FBG

ALT

AST

TC

TG and LDL-C levels were comparable between the two groups（P>0.05）;after intervention

all of these levels were reduced in both groups

with greater reductions in the trial group（P<0.05）.Before intervention

the HOMA-IR and FLI were similar between the two groups（P>0.05）;after intervention

they were reduced in both groups

with greater reductions in the trial group（P<0.05）.Conclusion For patients with type 2 diabetes and NAFLD

optimized healthy behavior intervention may enhance treatment response

improve blood lipid and liver enzyme values

reduce HOMA-IR and FLI

and thus deserves widespread clinical application.