Objective To investigate the efficacy of irinotecan combined with cisplatin and fluorouracil（5-FU）for advanced gastric cancer.Methods From January 2010 to December 2016

104 patients with advanced gastric cancer admitted in a hospital in Chongqing were selected as the research objects and divided into experimental group and control group using the random number table

52 cases in each group.In control group patients treated with cisplatin and 5-FU

while in the experimental group patients were treated with irinotecan plus the treatment of the control group.The efficacy

adverse reactions and prognosis of two groups′treatments were compared.Results The total effective rate and disease control rate of experimental group were50.00% and 84.62% respectively

which were higher than 30.76% and 65.38% of control group

and the difference had statistical significance（P

<

0.05）.The incidence of leukopenia

thrombocytopenia

diarrhea and abnormal liver function of experimetal group were 80.77%

34.62%

30.77% and 44.23%

and they were higher than 42.31%

9.62%

7.69% and 23.08% of control group

and the difference had statistical significance（P

<

0.05）.The overall survival（OS）of patients in experimental group was 3

2

8months

and the median OS was 21months;In control group patients′OS was 3

2

3months

and the median OS was 16 months.The experimental group patients′OS was longer than the control group

and the difference was statistically significant（P

<

0.05）.Conclusion The combination of irinotecan

cisplatin and 5-FU for advanced gastric cancer is effective obviously and it can improve the prognosis of patients

it is also easy to cause adverse reactions like leukopenia

thrombocytopenia

diarrhea and abnormal liver function

so monitoring adverse reactions closelyis required in the treatment.