Objective To study the curative effect of high-dose gamma globulin intravenous infusion on children in patients with Kawasaki disease.Methods 78 children with Kawasaki disease from Apr.2012 to Dec.2014 in one of Xiantao hospitals were selected and randomly divided into observation group and control group.The observation group（40cases）received high-dose intravenous gamma globulin treatment

and the control group（38cases）received conventional-dose intravenous gamma globulin treatment.Then symptoms disappearing time

hospital stays and laboratory indexes were compared between two groups.Results Clinical symptoms of fever

swollen lymph nodes

mucosal congestion and foot hard swelling of observation group lasted for（1.75±0.54）d

（2.02±0.25）d

（1.82±0.25）d and（1.02±0.21）d respectively

which was shorter than the time of control group（（3.06±0.63）d

（2.56±0.35）d

（2.41±0.30）d

（1.53±0.28）d）（P<0.05）.Hospital stays of observation group（7.51±0.86）d was shorter than that of control group（10.34±1.26）d after treatment（P<0.05）.Indexes of NT-proBNP

BNP

PCT and CRP of observation group were significantly lower than those of control group（P<0.05）.Indexes of IgA and IgG of observation group were higher than those of control group after treatment（P<0.05）.Conclusion The high-dose intravenous gamma globulin helps relieve clinical symptoms quickly

relieve inflammation

ease myocardial injury

and improve body′s immune function.