Objective To investigate the cognition and attitude of human papilloma virus and its vaccines among female college students so as to provide a theoretical reference for the prophylactic HPV vaccination.Methods With convenience sampling method

female college students from 10 universities in Guangzhou university town were taken questionnaires and 585 were valid questionnaires.Results 157（26.8%）female students heard of HPV

but only 89（15.2%）heard of prophylactic HPV vaccines.441（75.4%）female students were willing to be vaccinated;395（67.5%）students favored the promotion of HPV vaccines in China

but 403（68.9%）could afford its price of less 500 yuan and 358（61.2%）hoped the nation could pay part of its price.The factors of HPV inoculation willingness were whether they heard of prophylactic HPV vaccines

whether they knew the best vaccination time and whether they knew they had to do routine gynecological screening after vaccination.Conclusions The cognition of HPV and prophylactic HPV vaccines among female college students is not high and it affects HPV inoculation willingness and the willingness to pay HPV vaccines is low.The nation need provide financial support and carry out health education programs of HPV vaccines to effectively increase the acceptance of prophylactic HPV vaccine among women.