The Significance of EBV VCA-IgA Antibodies in the Detection Before and After the Treatment of Locally Advanced Nasopharyngeal Carcinoma and Its Relation with the Clinical Features of Patients

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The Significance of EBV VCA-IgA Antibodies in the Detection Before and After the Treatment of Locally Advanced Nasopharyngeal Carcinoma and Its Relation with the Clinical Features of Patients

更新时间：2021-08-23

- The Significance of EBV VCA-IgA Antibodies in the Detection Before and After the Treatment of Locally Advanced Nasopharyngeal Carcinoma and Its Relation with the Clinical Features of Patients
- Health Medicine Research and Practice Vol. 12, Issue 6, Pages: 36-39(2015)
- 作者机构：
  
  1. 福建医科大学附属第一医院放疗科
  2. 放射生物福建省高等学校重点实验室(福建医科大学)
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.63
- Published：2015，
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[1]邹喜,张纬建,洪金省,陈金梅,刘锋.EBV VCA-IgA抗体在局部晚期鼻咽癌治疗前后检测的意义及与患者临床特征的关系[J].保健医学研究与实践,2015,12(06):36-39.

The Significance of EBV VCA-IgA Antibodies in the Detection Before and After the Treatment of Locally Advanced Nasopharyngeal Carcinoma and Its Relation with the Clinical Features of Patients. [J]. Health Medicine Research and Practice 12(6):36-39(2015)
[1]邹喜,张纬建,洪金省,陈金梅,刘锋.EBV VCA-IgA抗体在局部晚期鼻咽癌治疗前后检测的意义及与患者临床特征的关系[J].保健医学研究与实践,2015,12(06):36-39. DOI：

The Significance of EBV VCA-IgA Antibodies in the Detection Before and After the Treatment of Locally Advanced Nasopharyngeal Carcinoma and Its Relation with the Clinical Features of Patients. [J]. Health Medicine Research and Practice 12(6):36-39(2015) DOI：

摘要

目的探讨局部晚期鼻咽癌患者治疗前后血清EB病毒衣壳抗原IgA（EBV VCA-IgA）抗体水平变化的临床意义及其与患者临床特征的关系。方法回顾性分析2014年3-10月在福建医科大学附属第一医院放疗科就诊的51例经病理证实为局部晚期鼻咽癌患者的病历资料

探讨治疗前患者血清EBV VCA-IgA水平与患者临床特征的关系

并对患者化放疗前后的EBV VCA-IgA水平进行配对比较。结果 51例患者治疗前EBV VCA-IgA的S/CO值为3.88（2.14

6.05）

EBV VCA-IgA抗体阳性率为94.1%

按不同性别、年龄、T分期、N分期、总分期、既往有无吸烟史进行分组比较

抗体阳性率差异均无统计学意义。诱导化疗2个周期后放疗前进行EBV VCA-IgA复查的患者有20例

与诱导化疗前进行配对比较

诱导化疗后EBV VCAIgA的S/CO值为3.99（2.09

5.22）

低于诱导化疗前的4.09（2.16

6.20）

但差异无统计学意义（Z=-0.845

P=0.398）;诱导化疗2个周期后放疗前EBV VCA-IgA抗体阳性率为85.0%

低于诱导化疗前的95.0%

但差异无统计学意义（χ

=-0.278

P=0.598）。诱导化疗2个周期+根治性放疗后进行了EBV VCAIgA复查的患者有31例

与治疗前进行配对比较

放疗后EBV VCA-IgA的S/CO值为2.30（1.35

5.20）

低于治疗前的3.91（2.20

6.43）

但差异无统计学意义（Z=-1.744

P=0.081）;诱导化疗2个周期+根治性放疗后EBV VCA-IgA抗体阳性率为87.1%

低于化放疗前的93.5%

但差异无统计学意义（χ

=-0.185

P=0.668）。结论 EBV VCA-IgA用于局部晚期鼻咽癌的治疗效果评估参考价值有限

其治疗前水平的临床影响因素尚有待进一步研究。

Abstract

Objective To investigate the clinical significance of changes of serum EB virus capsid antigen IgA（EBV VCA-IgA）antibodies in the detection before and after the treatment of locally advanced nasopharyngeal carcinoma and its relation with the clinical features of patients.Methods Medical records of 51 cases of patients with locally advanced nasopharyngeal carcinoma pathologically confirmed from March to October 2014 in the first Affiliated Hospital of Fujian Medical University were retrospectively analyzed to explore the relation between levels of pre-treatment serum EBV VCA-IgA and patients′clinical features and compare the EBV VCA-IgA levels before and after radiotherapy.Results Before treatment

the value of S/CO of EBV VCAIgA was 3.88（2.14

6.05）

the positive rate of EBV VCA-IgA antibodies was 94.1%

and there were no significant differences of positive rates in groups of different gender

age

T stage

N stage

overall stage and smoking history.20 cases of patients were reexamined EBV VCA-IgA after two courses of induction chemotherapy before radiotherapy;the value of S/CO of EBV VCA-IgA after chemotherapy was 3.99（2.09

5.22）

lower than 4.09（2.16

6.20）of before chemotherapy

but the difference was not statistically significant（Z=-0.845

P=0.398）;the positive rate of EBV VCA-IgA antibodies was 85.0%

less than 95.0% of before chemotherapy and the difference was not statistically significant（χ

=-0.278

P=0.598）.31 cases of patients were reexamined EBV VCA-IgA after two courses of induction chemotherapy and radical radiotherapy;the value of S/CO of EBV VCA-IgA after radiotherapy was 2.30（1.35

5.20）

lower than 3.91（2.20

6.43）of before treatment

but the difference was not statistically significant（Z=-1.744

P=0.081）;the positive rate of EBV VCA-IgA antibodies after chemotherapy and radiotherapy was 87.1%

less than 93.5% of before chemotherapy and the difference was not statistically significant（χ

=-0.185

P=0.668）.Conclusions The reference value of EBV VCA-IgA in evaluating the treatment efficacy of locally advanced nasopharyngeal carcinoma is limited and its clinical factors of pre-treatment EBV VCA-IgA levels remain to be further studied.

关键词

EB病毒衣壳蛋白抗体鼻咽癌化疗放疗临床特征

Keywords

EB virus capsid protein antibodyNasopharyngeal carcinomaChemotherapyRadiotherapyclinical features

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