Objective To evaluate the bacteriostatic activity of mangiferin against three types of common periodontal pathogenic bacteria.Method To adopt broth dilution method to measure the MIC and MBC of mangiferin on P.gingivalis

P.intermedia

and F.nucleatum

and draw graphs of sterilizing time graphs of Mangiferin against the three bacteria.Results The MIC values of mangiferin against P.gingivalis

P.intermedia

and F.nucleatum were 2.50mg/mL

5.00mg/mL

2.50mg/mL respectively

and the MBC values of mangiferin against the same three bacteria were 10.00mg/mL

20.00mg/mL

10.00mg/mL respectively.When the degree of concentration of mangiferin reached the MIC values against the three bacteria

marked bacteriostatic effect was observed on all of them.When the degree of concentration of mangiferin reached the MBC values against the three bacteria

bacteriostatic effect was observed on P.gingivalis and F.nucleatum in one hour

and on P.intermedia in two hours.Conclusion Mangiferin has good bacteriostatic and bactericidal effects on the three common periodontal pathogenic bacteria.