Intervention Mechanism of Hydrogen Saline on Brain lnjury in Rats After Cardiopulmonary Resuscitation

Jiang Yu; Liao Yang; Luo Chun; Liu Gang

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Intervention Mechanism of Hydrogen Saline on Brain lnjury in Rats After Cardiopulmonary Resuscitation

更新时间：2021-08-23

- Intervention Mechanism of Hydrogen Saline on Brain lnjury in Rats After Cardiopulmonary Resuscitation
- Health Medicine Research and Practice Vol. 12, Issue 3, Pages: 10-12(2015)
- 作者机构：
  
  重庆医科大学附属大学城医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R459.7
- Published：2015，
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[1]江宇,廖洋,罗春,刘刚.氢盐水对心肺复苏后大鼠脑损伤的干预机制研究[J].保健医学研究与实践,2015,12(03):10-12.

Jiang Yu, Liao Yang, Luo Chun, et al. Intervention Mechanism of Hydrogen Saline on Brain lnjury in Rats After Cardiopulmonary Resuscitation. [J]. Health Medicine Research and Practice 12(3):10-12(2015)
[1]江宇,廖洋,罗春,刘刚.氢盐水对心肺复苏后大鼠脑损伤的干预机制研究[J].保健医学研究与实践,2015,12(03):10-12. DOI：

Jiang Yu, Liao Yang, Luo Chun, et al. Intervention Mechanism of Hydrogen Saline on Brain lnjury in Rats After Cardiopulmonary Resuscitation. [J]. Health Medicine Research and Practice 12(3):10-12(2015) DOI：

摘要

目的探讨氢盐水对心肺复苏（CPR）后大鼠脑损伤的干预程度及机制。方法将18只雄性清洁级SD大鼠随机分为对照组（Con组）、常规复苏组（ROSC组）和氢盐水干预组（ROSC+HRS组）

每组6只

建立CPR大鼠模型

于自主循环恢复后12h行神经功能缺损评分（NDS）

并测定大鼠脑组织含水量及脑组织匀浆丙二醛（MDA）含量。结果 ROSC+HRS组大鼠NDS评分明显高于ROSC组

脑组织含水量明显低于ROSC组

脑组织匀浆MDA含量明显低于ROSC组

差异均有统计学意义（P<0.05）。结论大鼠CPR后常出现神经元细胞坏死、脑水肿

利用氢盐水干预CPR大鼠可减轻大鼠CPR后的脑损伤

可能与氢盐水能减轻CPR引起的氧化应激损伤有关。

Abstract

Objective To investigate the level of intervention and mechanism of hydrogen saline on brain injury in rates after cardiopulmonary resuscitation（CPR）.Method 18 male Sprague-Dawley（SD）rats were randomly divided into a control group（Con group）

a resuscitation of spontaneous circulation group（ROSC group）and an intervention group of hydrogen saline（ROSC+ HRS group）

6rats in every group

to establish CPR model and take neurological deficit scores（NDS）after 12 hours of recovery of spontaneous circulation and to measure the water content and the malondialdehyde（MDA）content of rat brain tissues.ResultsROSC+HRS group had a significantly higher NDS and much lower water content and MDA content of brain tissues than ROSC group

the differences were statistically significance（P <0.05）.Conclusion Rats often have neurons necrosis and cerebral edema after CPR and the intervention of hydrogen saline can reduce their brain injury in rats

probably because hydrogen saline may relieve the oxidative injury induced by CPR.

关键词

心肺复苏脑损伤氢盐水

Keywords

Cardiopulmonary resuscitationBrain injuryHydrogen saline

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