Objective To observe the curative effect of alprostadil injection in the treatment of vertebrobasilar insufficiency.Method 65 patients with vertebral basilar artery insufficiency were randomly divided into study group of alprostadil（34patients）and control group of low molecular weight dextran conbined with compound dansen injection（31patients）

and to compare the curative effect of the two groups.Results The total efficiency of study group（91.2%）was higher than that of control group（67.7%）

and the difference was statistically significant.Conclusion The curative effect of alprostadil injection on curing vertebrobasilar insufficiency is remarkable

which is worthy of popularization.