Nuclear Factors of Lung Tissues from Hydrogen Sulfide Acute Poisoned Rats

LIU Gang; JIANG Yu; GE Yun

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Nuclear Factors of Lung Tissues from Hydrogen Sulfide Acute Poisoned Rats

更新时间：2021-08-23

- Nuclear Factors of Lung Tissues from Hydrogen Sulfide Acute Poisoned Rats
- Health Medicine Research and Practice Vol. 11, Issue 3, Pages: 4-7(2014)
- 作者机构：
  
  1. 重庆医科大学附属大学城医院
  2. 杭州市滨江医院急诊科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R595.1
- Published：2014，
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[1]刘刚,江宇,葛赟.硫化氢急性中毒大鼠肺组织核因子κB变化及乌司他丁的干预作用[J].保健医学研究与实践,2014,11(03):4-7.

LIU Gang, JIANG Yu, GE Yun. Nuclear Factors of Lung Tissues from Hydrogen Sulfide Acute Poisoned Rats. [J]. Health Medicine Research and Practice 11(3):4-7(2014)
[1]刘刚,江宇,葛赟.硫化氢急性中毒大鼠肺组织核因子κB变化及乌司他丁的干预作用[J].保健医学研究与实践,2014,11(03):4-7. DOI：

LIU Gang, JIANG Yu, GE Yun. Nuclear Factors of Lung Tissues from Hydrogen Sulfide Acute Poisoned Rats. [J]. Health Medicine Research and Practice 11(3):4-7(2014) DOI：

摘要

目的探讨硫化氢（H2S）急性中毒大鼠肺组织核因子κB（NF-κB）含量、分布的动态变化及乌司他丁（UTI）对其的干预作用。方法将SD大鼠88只随机分为对照组、H2S组和H2S+UTI组

用免疫组化法观察肺组织NF-κB含量及分布。结果与对照组比较

H2S组2h

12h

24h

48h时间点大鼠肺组织NF-κB蛋白表达均明显升高（P<0.05）;与同时间点H2S组比较

H2S+UTI组2h

12h

24h

48hNF-κB蛋白表达均明显降低（P<0.05）。NF-κB蛋白除可在肺泡上皮细胞表达外

还可分布于气道黏膜上皮细胞、炎性浸润细胞（主要是中性粒细胞和巨噬细胞）中。结论 H2S吸入性中毒急性肺损伤大鼠早期肺组织中NF-κB表达增加

而UTI干预治疗能显著降低NF-κB表达。

Abstract

Objective To investigate the content and its distribution of dynamic change of nuclear factorκB（NF-κB）of lung tissues from hydrogen sulfide（H2S）acute poisoned rats and the intervention effects of ulinastatin（UTI）on it.Method 88SD rats were randomly divided into control group

H2S group and H2S+UTI group and the content and distribution of NF-κB in all groups were observed with the method of immunohistochemistry.Results The protein expressions of NF-κB in the lung tissues of rats in the H2S group increased mor significantly than the control group at the time points of 2

24and 48hours（P<0.05）;the protein expressions of NF-κB in the H2S+UTI group were significantly lower than H2S group at the same time points of 2

24and 48hours（P<0.05）.NF-κB protein could not only express in alveolar epithelial cells

but also distribute in the tracheal epithelial cells and inflammatory infiltration cells（mainly in neutrophils and macrophages）.Conclusion The expression of NF-κB in the lung tissue from rats with H2S inhalation toxicity and acute lung injury increases in the early stage but the treatment of UTI intervention can significantly reduce its expression.

关键词

硫化氢乌司他丁急性肺损伤核因子κB

Keywords

Hydrogen sulfideUlinastatinAcute lung injuryNuclear factorκB

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