Objective To observe the effect of preventing marital spouse and mother-to-fetus transmission of HIV after the intervention of people carrying human immunodeficiency virus（HIV）positive.Method 21cases of people with confirmed HIV positive in their premarital medical examinations received in Fangcheng district from 2011to 2012and their spouses were adopted integrated intervention.Results Before the intervention

none of 21cases of patients informed their spouses of their disease and used condoms.After the intervention

17of them informed their spouses on their own initiative with a informing rate of 80.95%;17couples kept using condoms with a utilization rate of 80.95%.13patients voluntarily accepted the treatment of antiviral drugs

accounting for 61.94%.Five women got pregnant without the knowledge of their disease and had specified delivery for the prevention of mother-to-child transmission（PMTCT）of HIV.The newborns were given artificial feeding with the use of antiviral drugs and their HIV tests were negative when they were one year old.One year after the diagnosis

eight spouses of 11non-divorced couples were tested no HIV antibodies and three spouses refused to take the test.Conclusion The integrated intervention of people with HIV positive can reduce its incidence in spouse and mother-to-fetus transmission of HIV and the preventive measures of its spouse and mother-to-fetus transmission are effective.