Objective To probe into the value of combined detection of urinary kidney injury molecule-1（Kim-1） and blood superoxide dismutase（SOD）in early diagnosis of diabetic nephropathy（DN）.Method A detection of urinary Kim-1

urinary albumin excretion rate（UAER）

blood SOD

serum creatinine（Scr）and blood urea nitrogen（BUN）in 30cases of patients with early DN

30cases of patients with non-proliferative diabetes mellitus（DM）and 30normal adults was conducted and the results were comparatively analyzed.Results Level of urinary Kim-1and blood SOD in the group with early DN and that with non-proliferative DM was higher than the control group

and the differences were statistically significant（p<0.05）;there was no statistically significant difference（p>0.05）in the level of blood Scr and BUN among the three groups;urinary Kim-1of patients in the group with early DN had positive correlations with UAER（r=0.974

p<0.05）

and SOD had negative correlations with UAER（r=-0.948

p<0.05）.Conclusion Kim-1may be involved in the development of DN by means of oxidative stress

and combined detection of urinary Kim-1and blood SOD has certain clinical values in early diagnosis of renal damage in patients with DN.