Objective To sum up the nursing experience of percutaneous transhepatic biliary drainage（PTBD） or percutaneous transhepatic gallbladder drainage（PTGD）during pregnancy.Method Clinical data and nursing method of 25cases of patients in which conservative treatment for acute cholecystitis and biliary tract infection during pregnancy was not effective and to whom PTBD or PTGD was given were analyzed retrospectively.Results General conditions of 25cases of patients were improved obviously and they all had full-term delivery.One case was transferred to the obstetrical department due to exhibition of salamarum poisoning symptoms and was improved after treatment.15cases of patients came back to the hospital to have surgical treatment 3～6 months after delivery.And the other cases had no recurrence after drainage tubes were removed 2～3months after delivery.Conclusion Timely and effective nursing measures can reduce operative risk in patients with acute cholecystitis and biliary tract infection during pregnancy and reduce the maternal and infant mortality rate.