Experimental Study on Anesthetic Effect of Ketamine in Combination with Diazepam on Miniature Pigs

HUANG Feng1; ZHANG Zhi-jian2; DING Zi-hai3

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Experimental Study on Anesthetic Effect of Ketamine in Combination with Diazepam on Miniature Pigs

更新时间：2021-08-20

- Experimental Study on Anesthetic Effect of Ketamine in Combination with Diazepam on Miniature Pigs
- Health Medicine Research and Practice Vol. 9, Issue 2, Pages: 4-6(2012)
- 作者机构：
  
  1. 佛山科学技术学院医学院外科实验中心
  2. 南方医科大学微创外科解剖学研究所
  3. 佛山科学技术学院体育学院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R614
- Published：2012，
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[1]黄峰,张志坚,丁自海.氯胺酮与安定合用对小型猪麻醉效果的实验研究[J].保健医学研究与实践,2012,9(02):4-6.

HUANG Feng1, ZHANG Zhi-jian2, DING Zi-hai3. Experimental Study on Anesthetic Effect of Ketamine in Combination with Diazepam on Miniature Pigs. [J]. Health Medicine Research and Practice 9(2):4-6(2012)
[1]黄峰,张志坚,丁自海.氯胺酮与安定合用对小型猪麻醉效果的实验研究[J].保健医学研究与实践,2012,9(02):4-6. DOI：

HUANG Feng1, ZHANG Zhi-jian2, DING Zi-hai3. Experimental Study on Anesthetic Effect of Ketamine in Combination with Diazepam on Miniature Pigs. [J]. Health Medicine Research and Practice 9(2):4-6(2012) DOI：

摘要

目的探讨氯胺酮与安定合用对小型猪实验研究的麻醉效果。方法对10头进行外科腹部手术实验的小型猪进行复合麻醉

先臀部深部肌肉注射安定（地西泮）0.5～0.8mg/kg

待5～10min后再臀部肌肉注射氯胺酮6～8mg/kg

观察麻醉显效时间、麻醉维持时间及镇痛效果

并监测麻醉过程中体温、呼吸、心率等生理指标及术中有无明显躁动、呕吐、肠管胀气、流涎等不良反应。结果小型猪成功麻醉10例

占100%。肌肉注射后（4.0±1.5）min进入麻醉状态

麻醉状态维持（88.5±13.5）min。麻醉期间手术肌肉松弛效果好

呼吸和心率平稳

无明显不良反应。结论采用氯胺酮与安定复合麻醉效果好

麻醉过程平稳

生命体征稳定

是较为简便、安全的小型猪麻醉方法

适合于耗时较长的手术或动物试验的开展。

Abstract

Objective To probe into the anesthetic effect of ketamine in combination with diazepam in the experimental research on miniature pigs.Method Ten miniature pigs experimentized with abdominal surgery were anesthetized with combined anesthesia.Deep buttock intramuscular injection with 0.5

.8 mg/kg diazepam was given first and then buttock intramuscular injection with 6

mg/kg ketamine was given 5

0 minutes later.The effectual time

effective time and analgesic effect of the anesthesia were observed;physiologic indexes such as temperature

breath and heart rate during anesthesia were monitored

and untoward effects such as evident dysphoria

vomit

flatulence and salivation during operation were observed.Results Ten miniature pigs were all successfully anesthetized with a percentage of 100%.Narcosis appeared（4.0±1.5） minutes after the intramuscular injection and lasted for（88.5±13.5） minutes.The muscle was well relaxed

and breath and heart rate were kept stable during anesthesia and there was no evident untoward effect.Conclusion Ketamine in combination with diazepam has good anesthetic effect

stationary anesthesia process and stable vital signs.It is a relatively simple and safe method to anesthetize the miniature pig and suitable to be used in time-consuming operations or animal experiments.

关键词

实验小型猪氯胺酮安定麻醉

Keywords

Experimental miniature pigsKetamineDiazepamAnesthesia

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