An Experimental Study on the Hypoglycemic Effect of Agar Polysaccharide in Diabetic Rats

WANG Hui ZHOU Xing TANG Fei ZUO Shu-hong

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An Experimental Study on the Hypoglycemic Effect of Agar Polysaccharide in Diabetic Rats

更新时间：2021-08-20

- An Experimental Study on the Hypoglycemic Effect of Agar Polysaccharide in Diabetic Rats
- Health Medicine Research and Practice Vol. 8, Issue 4, Pages: 8-10(2011)
- 作者机构：
  
  海南省药物研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2011，
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[1]王慧,周星,唐菲,卓书洪.石花菜多糖对糖尿病大鼠降血糖作用的实验研究[J].保健医学研究与实践,2011,8(04):8-10.

WANG Hui ZHOU Xing TANG Fei ZUO Shu-hong. An Experimental Study on the Hypoglycemic Effect of Agar Polysaccharide in Diabetic Rats. [J]. Health Medicine Research and Practice 8(4):8-10(2011)
[1]王慧,周星,唐菲,卓书洪.石花菜多糖对糖尿病大鼠降血糖作用的实验研究[J].保健医学研究与实践,2011,8(04):8-10. DOI：

WANG Hui ZHOU Xing TANG Fei ZUO Shu-hong. An Experimental Study on the Hypoglycemic Effect of Agar Polysaccharide in Diabetic Rats. [J]. Health Medicine Research and Practice 8(4):8-10(2011) DOI：

摘要

目的研究石花菜多糖的降血糖作用。方法建立大鼠四氧嘧啶糖尿病模型

筛选50只血糖>16.1mmol/L的大鼠随机分为5组:石花菜多糖高剂量组（2 400mg/kg）、中剂量组（1 200mg/kg）、低剂量组（600mg/kg）

格列吡嗪治疗组（1.8mg/kg）

模型对照组。观察不同剂量的石花菜多糖对血糖、血清胰岛素和胰高血糖素的影响。结果石花菜多糖高剂量组、中剂量组可降低四氧嘧啶糖尿病大鼠的血糖

与模型对照组比较差异均有统计学意义（P<0.05或P<0.01）。高剂量组能提高胰岛素水平

降低胰高血糖素浓度

与模型对照组比较差异均有统计学意义（P<0.01）。结论石花菜多糖对糖尿病大鼠有降血糖作用。

Abstract

Objective To explore the hypoglycemic effect of gelidium amansii polysaccharide.Method The rat alloxan-induced diabetic model was established and 50 rats with their blood glucose >16.1 mmol/L were chosen and ramdonly divided into five groups: namely group with high-dose gelidium amansii polysaccharide（2400 mg/kg）

group with medium gelidium amansii polysaccharide（1 200 mg/kg）

group with low-dose gelidium amansii polysaccharide（600 mg/kg）

group treated with glipizide（1.8 mg/kg） and the model control group.The effect of different dosages of gelidium amansii polysaccharide on blood glucose

serum insulin and glucagon were observed.Results The group with high-dose and medium gelidium amansii polysaccharide may reduce the blood glucose of alloxan-induced diabetic rats and compared with the model control group

each difference was statistically significant（P<0.05 or P<0.01）.The group with high-dose agar polysaccharide could improve the insulin level

reduce the concentration of glucagon

and the difference

compared with the model control group

was statistically significant（P<0.01）.Conclusion The gelidium amansii polysaccharide has hypoglycemic effect in diabetic rats.

关键词

石花菜多糖降血糖作用血糖胰岛素胰高血糖素

Keywords

Agar polysaccharideHypoglycemic effectBlood glucoseInsulinGlucagon

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