Objective      To determine the curative effect of Fuzheng Huayu Capsule (a prescription of traditional Chinese medicine based on anti-viral herbs) combined with tenofovir in treatment of hepatitis B liver fibrosis.  Methods     Clinical data of 116 patients with chronic hepatitis B liver fibrosis who admitted in the Southwest Hospital and the Affiliated Hospital of North China University of Science and Technology from July 2014 to January 2016 were collected and retrospectively analyzed. According to their treatment

the patients were divided into the single drug group (n=56

300 mg/d tenofovir

once per day

for 72 weeks) and the combined group (n=60

tenofovir at the same dose and course as the single drug group combined with 1.5 g Fuzheng Huayu Capsule

3 times per day

for 72 weeks). The liver function

HBV DNA copy number

HBV serological indicators

  liver fibrosis indicators were measured

and abdomen ultrasonography and Fibroscan testing was carried out before and after the treatment. The above indicators and results were compared between the 2 groups.  Results     The liver function were returned to normal in the both groups of patients. The proportion of the patients with HBV DNA 500 copy/mL was 82.14% (46/56) in the single drug group and 86.67% (52/60) in the combined group

without significant difference (P0.05). The rate of HBeAg sero-conversion was 21.43% (12/56) in the former and 23.33% (14/60) in the latter group

and no statistical significance was found (P0.05). The 4 indicators of liver fibrosis were significantly lower in the combined group than the single drug group (P0.05). After treatment

abdominal ultrasound examination showed that obvious differences were seen in portal vein diameter and blood flow velocity

spleen length and portal blood flow between the 2 groups (P0.05). The liver stiffness measure (LSM) values were decreased after treatment

and statistical significance was observed between the 2 groups (P0.05).  Conclusion     Combination of Fuzheng Huayu Capsule and tenofovir is more effective  in the treatment of hepatitis B liver fibrosis

and it is worthy of clinical promotion.