Characteristics of nondyskinesias in idiopathic REM sleep disorder

陈静; 李延萍

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Characteristics of nondyskinesias in idiopathic REM sleep disorder

更新时间：2026-01-09

- Characteristics of nondyskinesias in idiopathic REM sleep disorder
- Journal of Army Medical University Vol. 38, Issue 22, Pages: 2462-2465(2016)
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  CLC： R338.63;R339.141;R741
- Published：2016
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陈静,李延萍.特发性快动眼期睡眠行为异常非运动障碍的特点[J].陆军军医大学学报(原第三军医大学学报),2016,38(22):2462-2465.

　Chen Jing,Li Yanping.Characteristics of nondyskinesias in idiopathic REM sleep disorder[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(22):2462-2465.
陈静,李延萍.特发性快动眼期睡眠行为异常非运动障碍的特点[J].陆军军医大学学报(原第三军医大学学报),2016,38(22):2462-2465. DOI：

　Chen Jing,Li Yanping.Characteristics of nondyskinesias in idiopathic REM sleep disorder[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(22):2462-2465. DOI：

摘要

目的通过分析快动眼期睡眠行为异常（idiopathic REM sleep disorder

iRBD）患者是否存在嗅觉减退、睡眠障碍、焦虑抑郁，来探讨iRBD患者的非运动障碍特点。方法收集我院2014年1月至2016年1月iRBD患者48例及健康对照组53例，分别对两组人群进行睡眠指标、嗅觉功能、焦虑抑郁量表以及血清中IL-6、TNF-α浓度的检测。结果 iRBD组与健康对照组比较，其总睡眠时间、睡眠效率明显降低(P0.05)；睡眠潜伏期、觉醒指数、快动眼睡眠潜伏期明显增高(P0.05)；嗅觉减退明显增多(P0.01)；焦虑抑郁评分明显增高(P0.05)；但两组人群血清中IL-6及TNF-α浓度差异没有统计学意义（P0.05）。结论 iRBD与帕金森病有类似的非运动障碍特点，早期干预iRBD人群有利于帕金森病患者的预防和治疗。

Abstract

Objective To study the characteristics of non-dyskinesias in （idiopathic REM sleep disorder

iRBD) patients by examining the possible symptoms of hyposmia

sleep disorders

anxiety and depression. Methods Forty-eight iRBD patients and 53 healthy people recruited from our hospital between Jan 2014 and Jan 2016 were studied as treatment and control groups. The subjects of the 2 groups were evaluated by factors including sleep indicators

olfactory function

anxiety and depression scale

and blood serum concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Results Compared with control group

total sleep time and sleep efficiency were significantly reduced in treatment group (P0.05). Also

sleep latency

awakening index and rapid eye movement (REM) sleep latency were significantly increased (P0.05)

along with more severe hyposmia and higher score of anxiety and depression in the treatment than control group (P0.05). But there were no significant differences in the serum levels of IL-6 and TNF-α between the 2 groups（P0.05）. Conclusion Patients with iRBD or Parkinson’s disease (PD) share similar symptoms of non-dyskinesias. Early intervention in iRBD patients will be of benefit to prevent and treat patients with PD.

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