Objective     To investigate the clinical efficiency of noninvasive ventilation therapy with continuous positive airway pressure on the uremia patients with acute left heart failure. Methods      Sixty-three uremia patients complicated with acute left heart failure admitted in our emergency depa

rtment from November 2013 to March 2016 were recruited into this study. The patients were randomly divided into control group (n=31

at a mean age of 46.2±13.2) and treatment group (n=32

at a mean age of 47.2±14.8). The patients from the both groups were treated by oxygen inhalation

cardiotonic agents

diuretic drugs

vasodilator treatment and other conventional drug treatment

and those of the treatment group were given the treatment of continuous positive airway pressure at the same time. The clinical manifestations

heart rate (HR)

respiratory rate (RR)

systolic blood pressure (SBP)

diastolic blood pressure (DBP) and arterial partial pressure of oxygen (PaO

2

) were measured and recorded in the beginning and after 2 hours’ treatment. The levels of blood brain natriuretic peptide (BNP) and lactate (Lac) were detected too. Results     After 2 hours’ treatment

the parameters in the treatment group were markedly improved when compared with the control group (HR: 96.7±9.1 vs 106.6±10.3 beats/min

RR: 21.0±1.6 vs 23.8±1.8 times/min

SBP: 140.1±9.2 vs 148.5±19.0 mmHg

DBP: 86.2±6.4 vs 98.8±10.2 mmHg

PaO2:96.6±5.7 vs 87.2±7.7 mmHg

BNP: 1 721.0±794.6 vs 2 226.4±760.1 ng/L

Lac: 3.50±1.27 vs 4.74±1.42 mmol/L

all P0.05). The proportion of emergent hemodialysis was significant lower (Chi square=14.385

P0.01)

and clinical response was obviously higher (Chi square=15.432

P0.01)after 2 hours’ treatment in the treatment group than the control group. Conclusion      Simultaneous noninvasive ventilation therapy with continuous positive airway pressure is safer and more effective for clinical manifestations and cardiac functions in the uremia patients with acute left heart failure.