Differential expression of DAB2IP in gastric carcinoma patients with different clinical prognoses

王瀚; 牛跃平; 董峰; 高健; 徐怀文

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Differential expression of DAB2IP in gastric carcinoma patients with different clinical prognoses

更新时间：2026-01-09

- Differential expression of DAB2IP in gastric carcinoma patients with different clinical prognoses
- Journal of Army Medical University Vol. 38, Issue 19, Pages: 2164-2167(2016)
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  CLC： R181.23;R730.23;R735.2
- Published：2016
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王瀚,牛跃平,董峰,高健,徐怀文.不同临床预后患者胃癌组织中DAB2IP表达的差异[J].陆军军医大学学报(原第三军医大学学报),2016,38(19):2164-2167.

　Wang Han,Niu Yueping,Dong Feng,Gao Jian,Xu Huaiwen.Differential expression of DAB2IP in gastric carcinoma patients with different clinical prognoses[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(19):2164-2167.
王瀚,牛跃平,董峰,高健,徐怀文.不同临床预后患者胃癌组织中DAB2IP表达的差异[J].陆军军医大学学报(原第三军医大学学报),2016,38(19):2164-2167. DOI：

　Wang Han,Niu Yueping,Dong Feng,Gao Jian,Xu Huaiwen.Differential expression of DAB2IP in gastric carcinoma patients with different clinical prognoses[J].J Amry Med Univ (J Third Mil Med Univ),2016,38(19):2164-2167. DOI：

摘要

目的探讨胃癌中人DOC-2/DAB-2交互蛋白(DOC-2/DAB-2 interaction protein，DAB2IP)的表达与临床预后生存时间的关系。方法收集82例正常胃黏膜及胃癌组织，采用免疫组化方法进行蛋白检测，对随访资料进行KaplanMeier生存分析和COX回归分析。结果 DAB2IP在正常胃黏膜组织中多以强阳性表达；在胃癌组织中阳性表达较少，多以弱阳性或阴性为主；DAB2IP在胃癌组织中的阳性评分低于正常黏膜，差异有统计学意义（P0.05）。DAB2IP阳性表达的胃癌患者中位生存时间为40.8个月，明显长于阴性表达患者的中位生存时间（33.7个月），差异有统计学意义（P0.05）。COX多因素回归分析显示，较低的DAB2IP表达水平和较高的TNM分期是胃癌预后生存时间的独立危险因素（P0.05）。结论 DAB2IP下调可能在胃癌的发生、发展中起一定的作用，对预测胃癌患者的预后生存时间具有一定的意义。

Abstract

Objective To investigate the correlation of the expression of DOC-2/DAB-2 interaction protein (DAB2IP) with prognosis of survival time in gastric carcinoma. Methods Immunohistochemistry was applied to detect the expression of DAB2IP in 82 tissue samples of gastric carcinoma and 82 normal stomach tissues. Kaplan-Meier survival analysis and COX regression analysis were used on the clinical and follow-up data. Results DAB2IP was highly expressed in the normal stomach tissues

but mildly or negatively in the gastric carcinoma (P0.05). The median survival time of the patients with positive expression of DAB2IP was 40.8 months

significantly longer than those with negative DAB2IP expression (33.7 months

P0.05). Furthermore

COX multivariate regression analysis demonstrated that the lower expression level of DAB2IP and higher TNM stage were independent prognostic factor for survival time of clinical prognosis (P0.05). Conclusion The declination of DAB2IP might play a significant role in the occurrence and development of gastric carcinoma

and it might of a vital significance on predicting the survival time in the patients with gastric carcinoma.

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