Expression and role of long non-coding RNA LINC00261 in Barrett’s esophagus and esophageal adenocarcinoma

刘月; 陈虹羽; 邵青; 毛高平; 宁守斌; 张亚飞

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Expression and role of long non-coding RNA LINC00261 in Barrett’s esophagus and esophageal adenocarcinoma

更新时间：2026-01-09

- Expression and role of long non-coding RNA LINC00261 in Barrett’s esophagus and esophageal adenocarcinoma
- Journal of Army Medical University Vol. 39, Issue 1, Pages: 67-71(2017)
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  CLC： R394.2;R730.23;R735.1
- Published：2017
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刘月,陈虹羽,邵青,毛高平,宁守斌,张亚飞.长链非编码RNA LINC00261在Barrett食管、食管腺癌组织中的表达及其作用[J].陆军军医大学学报(原第三军医大学学报),2017,39(01):67-71.

　Liu Yue,Chen Hongyu,Shao Qing,Mao Gaoping,Ning Shoubin,Zhang Yafei.Expression and role of long non-coding RNA LINC00261 in Barrett’s esophagus and esophageal adenocarcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2017,39(01):67-71.
刘月,陈虹羽,邵青,毛高平,宁守斌,张亚飞.长链非编码RNA LINC00261在Barrett食管、食管腺癌组织中的表达及其作用[J].陆军军医大学学报(原第三军医大学学报),2017,39(01):67-71. DOI：

　Liu Yue,Chen Hongyu,Shao Qing,Mao Gaoping,Ning Shoubin,Zhang Yafei.Expression and role of long non-coding RNA LINC00261 in Barrett’s esophagus and esophageal adenocarcinoma[J].J Amry Med Univ (J Third Mil Med Univ),2017,39(01):67-71. DOI：

摘要

目的探讨长链非编码RNA LINC00261在Barrett食管、食管腺癌组织中的表达及其可能作用机制。方法利用qRT-PCR检测LINC00261在中国人群正常食管鳞状上皮、Barrett食管及食管腺癌组织标本中的表达水平变化。并建立了以人胚胎干细胞为细胞模型。结果在Barrett食管及食管腺癌组织标本中，LINC00261表达较正常食管鳞状上皮组织均显著上调（P0.01）；酸暴露及胆酸可诱导人胚胎干细胞LINC00261表达显著上调并抑制FOXA2蛋白表达水平（P0.05），而LINC00261慢病毒载体转染亦可诱导FOXA2蛋白表达水平下调；上调FOXA2表达可阻断人胚胎干细胞在酸暴露及胆酸诱导下CDX2表达及细胞分化表型（柱状上皮标志物MUC2表达）的变化。结论 LINC00261在Barrett食管的发生过程中发挥关键作用，其可能通过抑制FOXA2表达参与相关调控。

Abstract

Objective To evaluate the expression of long non-coding RNA

LINC00261

in Barrett’s esophagus and esophageal adenocarcinoma

and to investigate its possible mechanism. Methods qRT-PCR was used to analyze the expression levels of LINC00261 in normal esophageal squamous epithelium

Barrett’s esophagus and esophageal adenocarcinoma of Chinese population. The possible role of LINC00261 in the development of Barrett’s esophagus was investigated in human embryonic stem cells. Results The expression level of LINC00261 were significantly higher in the Barrett’s esophagus and esophageal adenocarcinoma than the normal esophageal squamous epithelium tissues (P0.01). Acid and bile exposure enhanced the expression of LINC00261 and inhibited the protein level of FOXA2 in human embryonic stem cells. While lentivirus-mediated up-regulation of LINC00261 also induced the inhibition of FOXA2 expression. What’s more

FOXA2 up-regulation blocked the expression of CDX2 and differentiation phenotype (expression of MUC2

a biomarker for columnar differentiation) in human embryonic stem cells induced by acid and bile exposure. Conclusion LINC00261 plays a key role in the development of Barrett’s esophagus

and FOXA2 is involved in the related regulation by inhibiting FOXA2.

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