Objective      To investigate the influencing factors of ventilator-associated pneumonia (VAP) in order to improve the ventilator care bundle (VCB) and decreasing the incidence of the VAP. Methods     A total of 204 patients receiving mechanical ventilation at intensive care unit (ICU) in our hospital from Jan to Dec 2013 was retrospectively analyzed for studying the influencing factors of VAP using multivariable logistic regression. Results     Of 204 ICU patients with the mechanical ventilation

35 had VAP with a incidence rate of 17.16%. The multivariate logistic analysis showed 7 factors influencing VAP

including the unimplemented VCB (OR=9.600

95%CI: 1.060～86.935)

  absence of continuous aspiration of subglottic secretions (OR=9.197

95%CI: 2.035～41.566)

  failure of ventilator management (OR=7.426

95%CI: 1.044～52.798)

  tracheotomy (OR=5.593

95%CI: 1.420～22.031)

smoking(OR=4.936

95%CI: 1.606～15.174)

more than 60 years old (OR=4.334

95%CI: 1.320～14.236)

and enteral nutrition (ET) (OR=0.218

95%CI: 0.061～0.779). Conclusion     Except ET is a protective factor

unimplemented VCB

absence of subglottic secretion drainage

failure of ventilator management

tracheotomy

smoking

and age over 60 are risk factors for VAP in mechanically ventilated ICU patients. Since these influencing factors are complicated and multi-sourced

it is necessary to take targeted intervention with close monitoring and strengthen the implement of VCB for reducing the incidence of VAP.